ALK Monoclonal Antibody (5A4) | Invitrogen MA5-11460 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ALK Monoclonal Antibody (5A4)

catalog :

MA5-11460

quantity :

1 mL

price :

US 616.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5A4

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human	Chen Q, Gu Y, Liu B. Clinicopathological characteristics of kidney mucinous tubular and spindle cell carcinoma. Int J Clin Exp Pathol. 2015;8:1007-12 pubmed
immunohistochemistry - paraffin section; human immunohistochemistry; human	Petrilli G, Lorenzi L, Paracchini R, Ubiali A, Schumacher R, Cabassa P, et al. Epstein-Barr virus-associated adrenal smooth muscle tumors and disseminated diffuse large B-cell lymphoma in a child with common variable immunodeficiency: a case report and review of the literature. Int J Surg Pathol. 2014;22:712-21 pubmed publisher
immunohistochemistry; human	Sozzi G, Martelli M, Conte D, Modena P, Pettirossi V, Pileri S, et al. The EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues. Haematologica. 2009;94:1307-11 pubmed publisher
immunohistochemistry; human	Passoni L, Longo L, Collini P, Coluccia A, Bozzi F, Podda M, et al. Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients. Cancer Res. 2009;69:7338-46 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ALK Monoclonal Antibody (5A4)

Catalog # :

MA5-11460

Quantity :

1 mL

Price :

US 616.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:40-1:80

Species :

Human

Clone :

5A4

Isotype :

IgG1

Storage :

4 C

Description :

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.

Immunogen :

Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript (419-520aa)

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:40-1:80

Aliases :

Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK

more info or order :

Invitrogen product webpage