CD21 Monoclonal Antibody (2G9) | Invitrogen MA5-11417 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD21 Monoclonal Antibody (2G9)

catalog :

MA5-11417

quantity :

500 uL

price :

US 464.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G9

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; loading ...; fig 3e	Garcia Hernandez M, Uribe Uribe N, Espinosa González R, Kast W, Khader S, Rangel Moreno J. A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression. Front Immunol. 2017;8:563 pubmed publisher
immunohistochemistry; human	Lorenzi L, Tabellini G, Vermi W, Moratto D, Porta F, Notarangelo L, et al. Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects. PLoS ONE. 2013;8:e80131 pubmed publisher
immunohistochemistry; mouse	Slight S, Rangel Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, et al. CXCR5? T helper cells mediate protective immunity against tuberculosis. J Clin Invest. 2013;123:712-26 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 2c immunohistochemistry; human	Lorenzi L, Lonardi S, Petrilli G, Tanda F, Bella M, Laurino L, et al. Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders. Hum Pathol. 2012;43:209-15 pubmed publisher
immunohistochemistry; human; 1:20	Demirkesen C, Tuzuner N, Esen T, Lebe B, Ozkal S. The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma. Leuk Res. 2011;35:1269-72 pubmed publisher
immunohistochemistry - paraffin section; human immunohistochemistry; human	Petrilli G, Lorenzi L, Paracchini R, Ubiali A, Schumacher R, Cabassa P, et al. Epstein-Barr virus-associated adrenal smooth muscle tumors and disseminated diffuse large B-cell lymphoma in a child with common variable immunodeficiency: a case report and review of the literature. Int J Surg Pathol. 2014;22:712-21 pubmed publisher
immunohistochemistry; human; 1:10	Jung S, Yim S, Hu H, Jung C, Lee S, Kim D, et al. Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor. Lung Cancer. 2010;70:152-7 pubmed publisher
immunohistochemistry; human	Horváth E, Mezei T, Pávai Z, Turcu M, Demian S, Toth E, et al. Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases. Rom J Morphol Embryol. 2009;50:399-406 pubmed
immunohistochemistry; human; 1:30	Vermi W, Lonardi S, Bosisio D, Uguccioni M, Danelon G, Pileri S, et al. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. J Pathol. 2008;216:356-64 pubmed publisher
	Hui Z, Zhang J, Ren Y, Li X, Yan C, Yu W, et al. Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC). Cell Death Dis. 2022;13:607 pubmed publisher
	Gallo M, Cacheux V, Vincent L, Bret C, Tempier A, Guittard C, et al. Leukemic non-nodal mantle cell lymphomas have a distinct phenotype and are associated with deletion of PARP1 and 13q14. Virchows Arch. 2016;469:697-706 pubmed
	Zheng Y, Zhou X, Xie J, Zhu H, Zhang S, Zhang Y, et al. IgM expression in paraffin sections distinguishes follicular lymphoma from reactive follicular hyperplasia. Int J Clin Exp Pathol. 2014;7:3264-71 pubmed

product information

Product Type :

Antibody

Product Name :

CD21 Monoclonal Antibody (2G9)

Catalog # :

MA5-11417

Quantity :

500 uL

Price :

US 464.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1:2, Immunohistochemistry (Paraffin): 1:10-1:20, Western Blot: 1:100-1:500

Species :

Human

Clone :

2G9

Isotype :

IgG1

Storage :

4 C

Description :

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.

Immunogen :

Recombinant protein encoding the external domain of human CD22.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:2, Immunohistochemistry (Paraffin): 1:10-1:20, Western Blot: 1:100-1:500

Aliases :

C3b/C4b receptor; C3-binding protein; C3BR; C3DR; C4BR; CD21; CD35; CD35 antigen; cell surface receptor for C3d; complement C3b/C4b receptor 1 (Knops blood group); complement C3d receptor; Complement C3d receptor (C3DR); complement C3d receptor 2; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3d/Epstein Barr virus) receptor 2; complement component 3b/4b receptor 1 (Knops blood group); complement component 3d receptor 2; complement component receptor 2; complement receptor 1 long isoform; complement receptor 2; complement receptor type 1; complement receptor type 1-like protein; complement receptor type 2; Complement Receptor type 2 (CR2); CR; CR1; Cr-1; CR1-L; Cr2; Cr-2; CVID7; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; expressed in B lymphocytes; KN; Knops blood group antigen; LOW QUALITY PROTEIN: complement receptor type 1; SLEB9

more info or order :

Invitrogen product webpage