CD2 Monoclonal Antibody (AB75) | Invitrogen MA5-11373 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD2 Monoclonal Antibody (AB75)

catalog :

MA5-11373

quantity :

500 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AB75

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:60; fig 1	Liu T, Weng S, Wang M, Huang W. Nontuberculous mycobacterial infection with concurrent IgG4-related lymphadenopathy. APMIS. 2016;124:216-20 pubmed publisher
immunocytochemistry; human immunohistochemistry; human	Güven Karataş S, Bayrak R, Sahin Balçık O, Yalcın K, Atıcı E, Akyıldız U, et al. Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature. Turk J Haematol. 2013;30:67-71 pubmed publisher
immunohistochemistry; human; 1:60	Chang I, Chen H, Ma M, Huang W. Anaplastic large cell lymphoma with paraneoplastic leukocytosis: a clinicopathological analysis of five cases. APMIS. 2011;119:794-801 pubmed publisher
	He H, Wang M, Huang W. Infectious mononucleosis mimicking malignant T-cell lymphoma in the nasopharynx: a case report and review of the literature. Int J Clin Exp Pathol. 2013;6:105-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD2 Monoclonal Antibody (AB75)

Catalog # :

MA5-11373

Quantity :

500 uL

Price :

US 480.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1:20, Immunohistochemistry (Paraffin): 1:30-1:60, Western Blot: 1:100-1:500

Species :

Human

Clone :

AB75

Isotype :

IgG1, kappa

Storage :

4 C

Description :

CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.

Immunogen :

Recombinant fragment encoding the external domain of the human CD2 protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:20, Immunohistochemistry (Paraffin): 1:30-1:60, Western Blot: 1:100-1:500

Aliases :

Cd2; CD2 antigen; CD2 antigen (p50), sheep red blood cell receptor; CD2 molecule; CD2R; cluster of differentiation 2; Erythrocyte receptor; FLJ46032; LFA2; LFA-2; LFA-3 receptor; Ly37; Ly-37; lymphocyte antigen 37; OX34; OX-34; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; Rosette receptor; SRBC; surface immunoglobulin superfamily molecule; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5

more info or order :

Invitrogen product webpage