| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; loading ...; fig 2d
- western blot knockout validation; mouse; loading ...; fig 2b
- immunohistochemistry; human; fig 1c
| Gibier J, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, et al. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1336-1349 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4c
| Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig 1h
| Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher |
- western blot; human; loading ...; fig 1c
| Zhang H, Ji J, Liu Q, Xu S. MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway. J Cell Physiol. 2019;: pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 5e
| Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn L, Rosenthal B, et al. A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Cell. 2019;176:790-804.e13 pubmed publisher |
- western blot; human; loading ...; fig 2
| Ahmad R, Alam M, Hasegawa M, Uchida Y, Al Obaid O, Kharbanda S, et al. Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer. 2017;16:33 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 4
| Yang Y, Fang J, Li D, Wang L, Ji N, Zhang J. Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review. Oncol Lett. 2016;11:3395-3402 pubmed |
- chromatin immunoprecipitation; human; loading ...; fig 3b
- immunohistochemistry; human; 1:200; fig 6b
- western blot; human; loading ...; fig 1b
| Engel B, Bowser J, Broaddus R, Carson D. MUC1 stimulates EGFR expression and function in endometrial cancer. Oncotarget. 2016;7:32796-809 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; fig 7
| Ferreira M, McKenna L, Zhang J, Reichert M, Bakir B, Buza E, et al. Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cell Mol Gastroenterol Hepatol. 2015;1:550-569 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200
| Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200
| Poncy A, Antoniou A, Cordi S, Pierreux C, Jacquemin P, Lemaigre F. Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015;404:136-48 pubmed publisher |
- immunocytochemistry; human; fig 3
- western blot; human; fig 3
| Li Q, Liu G, Yuan H, Wang J, Guo Y, Chen T, et al. Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells. Oncotarget. 2015;6:4253-65 pubmed |
- immunohistochemistry; mouse; 1:200
| von Figura G, Fukuda A, Roy N, Liku M, Morris Iv J, Kim G, et al. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014;16:255-67 pubmed publisher |
- immunohistochemistry; human; 1:500
- western blot; human; 1:3000
| Bouillez A, Gnemmi V, Gaudelot K, Hemon B, Ringot B, Pottier N, et al. MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway. Oncotarget. 2014;5:754-63 pubmed |
- immunocytochemistry; human; 1:100
| Huang S, Islam M, O NEILL J, Hu Z, Yang Y, Chen Y, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32:84-91 pubmed publisher |
| Xu X, Padilla M, Li B, Wells A, Kato K, Tellez C, et al. MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res. 2014;74:460-70 pubmed publisher |
- immunoprecipitation; human
| Liu S, Yin L, Stroopinsky D, Rajabi H, Puissant A, Stegmaier K, et al. MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells. Blood. 2014;123:734-42 pubmed publisher |
- chromatin immunoprecipitation; human
- immunocytochemistry; human
- western blot; human
| Alam M, Ahmad R, Rajabi H, Kharbanda A, Kufe D. MUC1-C oncoprotein activates ERK?C/EBP? signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells. J Biol Chem. 2013;288:30892-903 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Puri S, García Núñez A, Hebrok M, Cano D. Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice. PLoS ONE. 2013;8:e72213 pubmed publisher |
- immunoprecipitation; mouse
| Wang F, Li Q, Ni W, Fang F, Sun X, Xie F, et al. Expression of human full-length MUC1 inhibits the proliferation and migration of a B16 mouse melanoma cell line. Oncol Rep. 2013;30:260-8 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Rajabi H, Alam M, Takahashi H, Kharbanda A, Guha M, Ahmad R, et al. MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene. 2014;33:1680-9 pubmed publisher |
- chromatin immunoprecipitation; human
| Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Jeliazkova P, Jörs S, Lee M, Zimber Strobl U, Ferrer J, Schmid R, et al. Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology. 2013;57:2469-79 pubmed publisher |
| Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, et al. Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci. 2013;104:266-73 pubmed publisher |
- immunohistochemistry; human; 1:100
| Ghosh S, Pantazopoulos P, Medarova Z, Moore A. Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues. Clin Breast Cancer. 2013;13:109-18 pubmed publisher |
- chromatin immunoprecipitation; human; 33 ug/ml
- western blot; human; 1:1000
| Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S, Yonezawa S. MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Oncogene. 2013;32:4614-21 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:300
| Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed publisher |
- immunohistochemistry; mouse
| Budiu R, Elishaev E, Brozick J, Lee M, Edwards R, Kalinski P, et al. Immunobiology of human mucin 1 in a preclinical ovarian tumor model. Oncogene. 2013;32:3664-75 pubmed publisher |
- western blot; African green monkey; 0.04 ug/ml
- immunohistochemistry; rhesus macaque; 0.4 ug/ml; fig 2
- immunocytochemistry; human; 0.67 ug/ml; fig 7
- western blot; human; 0.04 ug/ml
| Kumar P, Kumar P, Lindberg L, Thirkill T, Ji J, Martsching L, et al. The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. PLoS ONE. 2012;7:e42712 pubmed publisher |
| Gao H, Chakraborty G, Lee Lim A, Mo Q, Decker M, Vonica A, et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell. 2012;150:764-79 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Jin C, Rajabi H, Pitroda S, Li A, Kharbanda A, Weichselbaum R, et al. Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS ONE. 2012;7:e39432 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Jin C, Rajabi H, Rodrigo C, Porco J, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013;32:2179-88 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human; 1:1000
| Rajabi H, Ahmad R, Jin C, Kosugi M, Alam M, Joshi M, et al. MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem. 2012;287:10703-13 pubmed publisher |
- immunocytochemistry; mouse; 1:500
| Prevot P, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, et al. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut. 2012;61:1723-32 pubmed publisher |
- immunohistochemistry; human
| Yonezawa S, Kitajima S, Higashi M, Osako M, Horinouchi M, Yokoyama S, et al. A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. Gastric Cancer. 2012;15:370-81 pubmed publisher |
| Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D. MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells. PLoS ONE. 2011;6:e28234 pubmed publisher |
| Houston M, Augenlicht L, Heerdt B. Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression. PLoS ONE. 2011;6:e25207 pubmed publisher |
| Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, et al. MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Blood. 2011;117:4863-70 pubmed publisher |
- chromatin immunoprecipitation; human
- immunoprecipitation; human
- western blot; human
| Ahmad R, Rajabi H, Kosugi M, Joshi M, Alam M, Vasir B, et al. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal. 2011;4:ra9 pubmed publisher |
- western blot; human; 1:1000
| Lilly A, Khanim F, Hayden R, Luong Q, Drayson M, Bunce C. Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone. Cancer Res. 2011;71:1177-86 pubmed publisher |
- immunohistochemistry; mouse
| Shimajiri Y, Kosaka Y, Scheel D, Lynn F, Kishimoto N, Wang J, et al. A mouse model for monitoring islet cell genesis and developing therapies for diabetes. Dis Model Mech. 2011;4:268-76 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:500; fig 1
| Kopinke D, Murtaugh L. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol. 2010;10:38 pubmed publisher |
- immunoprecipitation; rat
- western blot; rat
| Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, et al. Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 2010;29:920-9 pubmed publisher |
- chromatin immunoprecipitation; human
- immunocytochemistry; human
- western blot; human
| Ahmad R, Raina D, Joshi M, Kawano T, Ren J, Kharbanda S, et al. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res. 2009;69:7013-21 pubmed publisher |
- immunohistochemistry; human; 1:500
| Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed publisher |
| Mikami Y, Hisatsune A, Tashiro T, Isohama Y, Katsuki H. Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line. Biochem Biophys Res Commun. 2009;379:1060-5 pubmed publisher |
- western blot; human; 1:200
| Mahanta S, Fessler S, Park J, Bamdad C. A minimal fragment of MUC1 mediates growth of cancer cells. PLoS ONE. 2008;3:e2054 pubmed publisher |
- blocking or activating experiments; human
- western blot; human
| Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, et al. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007;9:1419-27 pubmed |
- immunohistochemistry; human; 1:100
| Wang Y, Gao J, Li Z, Jin Z, Gong Y, Man X. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Int J Cancer. 2007;121:2716-22 pubmed |
- immunohistochemistry; mouse; 1:200
| Liu C, Chen Z, Chen Z, Zhang T, Lu Y. Multiple tumor types may originate from bone marrow-derived cells. Neoplasia. 2006;8:716-24 pubmed |
- immunocytochemistry; mouse
| Han J, Cao S, Jin H, Liu Y, Wang M, Song J, et al. Localization of putative stem cells and four cell populations with different differentiation degree in mouse mammary anlagen. Histochem Cell Biol. 2006;126:35-43 pubmed |
| Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, et al. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J Immunol. 2005;174:2376-86 pubmed |
| Yamashita N, Withers H, Morimoto Y, Bhattacharya A, Haratake N, Daimon T, et al. MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells. iScience. 2023;26:108168 pubmed publisher |
| Bhattacharya A, Fushimi A, Wang K, Yamashita N, Morimoto Y, Ishikawa S, et al. MUC1-C intersects chronic inflammation with epigenetic reprogramming by regulating the set1a compass complex in cancer progression. Commun Biol. 2023;6:1030 pubmed publisher |
| Wei D, Wang L, Liu Y, Hafley M, Tan L, Lorenzi P, et al. Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression. Dig Dis Sci. 2023;68:3043-3058 pubmed publisher |
| Aftab F, Rodriguez Fuguet A, Silva L, Kobayashi I, Sun J, Politi K, et al. An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. Br J Cancer. 2023;128:1647-1664 pubmed publisher |
| Alradhi M, Wen S, Safi M, Al Danakh A, Wang H, Shopit A, et al. Molecular genetic and clinical characteristic analysis of primary signet ring cell carcinoma of urinary bladder identified by a novel OR2L5 mutation. Cancer Med. 2023;12:3931-3951 pubmed publisher |
| Yamashita N, Morimoto Y, Fushimi A, Ahmad R, Bhattacharya A, Daimon T, et al. MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer. Mol Cancer Res. 2023;21:274-289 pubmed publisher |
| Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, et al. The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization. Cell Death Dis. 2022;13:899 pubmed publisher |
| Konkimalla A, Konishi S, Kobayashi Y, Kadur Lakshminarasimha Murthy P, Macadlo L, Mukherjee A, et al. Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration. iScience. 2022;25:105114 pubmed publisher |
| Sheng Y, Davies J, Wang R, Wong K, Giri R, Yang Y, et al. MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis. Cell Mol Gastroenterol Hepatol. 2022;14:789-811 pubmed publisher |
| Iverson E, Griswold K, Song D, Gagliardi T, Hamidzadeh K, Kesimer M, et al. Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium. MBio. 2022;:e0105522 pubmed publisher |
| Morimoto Y, Fushimi A, Yamashita N, Hagiwara M, Bhattacharya A, Cheng J, et al. Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment. Oncogene. 2022;41:3511-3523 pubmed publisher |
| Yamashita N, Fushimi A, Morimoto Y, Bhattacharya A, Hagiwara M, Yamamoto M, et al. Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher |
| Smith R, Zhang H, Hu S, Yung T, Francis R, Lee L, et al. Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions. Nat Commun. 2022;13:2965 pubmed publisher |
| Zindl C, Witte S, Laufer V, Gao M, Yue Z, Janowski K, et al. A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts. Immunity. 2022;55:494-511.e11 pubmed publisher |
| Johansson E, Liang S, Moccia C, Carlsson T, Andersson D, Fagman H, et al. Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland. Front Endocrinol (Lausanne). 2021;12:760541 pubmed publisher |
| Hyun S, Imamura A, Ishida H, Piepenbrink K, Goldblum S, Lillehoj E. The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling. J Biol Chem. 2021;297:101337 pubmed publisher |
| Luan Z, Morimoto Y, Fushimi A, Yamashita N, Suo W, Bhattacharya A, et al. MUC1-C Dictates Neuroendocrine Lineage Specification in Pancreatic Ductal Adenocarcinomas. Carcinogenesis. 2021;: pubmed publisher |
| Flasse L, Yennek S, Cortijo C, Barandiaran I, Kraus M, Grapin Botton A. Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity. Cell Rep. 2020;31:107677 pubmed publisher |
| Seymour P, Collin C, Egeskov Madsen A, Jørgensen M, Shimojo H, Imayoshi I, et al. Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 2020;52:731-747.e8 pubmed publisher |
| Jobbagy S, Vitturi D, Salvatore S, Pires M, Rowart P, Emlet D, et al. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus. JCI Insight. 2020;5: pubmed publisher |
| Lee B, Ahn C, Jeon B, Jung E, Yoo Y, Jeung E. Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion. J Physiol Pharmacol. 2019;70: pubmed publisher |
| Lee K, Kim H, Lee J, Oh C, Song H, Kim H, et al. Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3. Diabetes Metab J. 2019;43:649-658 pubmed publisher |
| Domenici G, Aurrekoetxea Rodríguez I, Simões B, Rábano M, Lee S, Millán J, et al. A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells. Oncogene. 2019;38:3151-3169 pubmed publisher |
| Lillehoj E, Guang W, Hyun S, Liu A, Hegerle N, Simon R, et al. Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection. J Biol Chem. 2019;294:662-678 pubmed publisher |
| Wang X, Yamada S, LaRiviere W, Ye H, Bakeberg J, Irazabal M, et al. Generation and phenotypic characterization of Pde1a mutant mice. PLoS ONE. 2017;12:e0181087 pubmed publisher |
| Woessner D, Lim C. Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation. Mol Pharm. 2013;10:270-7 pubmed publisher |
| Landsman L, Nijagal A, Whitchurch T, Vanderlaan R, Zimmer W, MacKenzie T, et al. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011;9:e1001143 pubmed publisher |
| Yin L, Huang L, Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J Biol Chem. 2004;279:45721-7 pubmed |
