product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-CREB (Ser133) Monoclonal Antibody (F.959.4)
catalog :
MA5-11192
quantity :
100 uL
price :
US 480.00
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
F.959.4
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 2a
Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed publisher
  • western blot; rat; loading ...; fig 5b
Bazzari F, Abdallah D, El Abhar H. Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats. Molecules. 2019;24: pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:50; fig 6f
  • western blot; rat; 1:500; fig 6a
Zhou Y, Chen S, Liu D, Manyande A, Zhang W, Yang S, et al. The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats. J Pain. 2017;18:933-946 pubmed publisher
Liu B, Guan F, Zhao J, Niu Y, Jiang H. BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABAB Receptor. Oxid Med Cell Longev. 2022;2022:4661519 pubmed publisher
Long X, Wu H, Zhou Y, Wan Y, Kan X, Gong J, et al. Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats. Front Nutr. 2022;9:852012 pubmed publisher
Ko H, Ahn S, Chang Y, Hwang I, Yun T, Sung D, et al. Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling. Stem Cell Res Ther. 2018;9:326 pubmed publisher
Chen S, Sun J, Zhou Y, Cao F, Braun C, Luo F, et al. Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades in rat models. Mol Pain. 2018;14:1744806918793232 pubmed publisher
Isensee J, Kaufholz M, Knape M, Hasenauer J, Hammerich H, Gonczarowska Jorge H, et al. PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination. J Cell Biol. 2018;217:2167-2184 pubmed publisher
Liu E, Xie A, Zhou Q, Li M, Zhang S, Li S, et al. GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory. Sci Rep. 2017;7:5781 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Phospho-CREB (Ser133) Monoclonal Antibody (F.959.4)
Catalog # :
MA5-11192
Quantity :
100 uL
Price :
US 480.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
ChIP Assay: 1:50, Flow Cytometry: 1:400-1:1,600, Immunohistochemistry (Frozen): 1:400-1:1,600, Immunohistochemistry (Paraffin): 1:400-1:1,600, Western Blot: 1:1,000
Species :
Human, Mouse, Rat
Clone :
F.959.4
Isotype :
IgG
Storage :
-20 C
Description :
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
Immunogen :
Synthetic phosphopeptide corresponding to residues surrounding pSer133 of human CREB
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 1:50, Flow Cytometry: 1:400-1:1,600, Immunohistochemistry (Frozen): 1:400-1:1,600, Immunohistochemistry (Paraffin): 1:400-1:1,600, Western Blot: 1:1,000
Aliases :
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA