CTCF Monoclonal Antibody (G.758.4) | Invitrogen MA5-11187 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CTCF Monoclonal Antibody (G.758.4)

catalog :

MA5-11187

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

G.758.4

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 1

Reference
Javasky E, Shamir I, Gandhi S, Egri S, Sandler O, Rothbart S, et al. Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns. Genome Res. 2018;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

CTCF Monoclonal Antibody (G.758.4)

Catalog # :

MA5-11187

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

ChIP Assay: 10 ul/10^6 cells, Immunocytochemistry: 1:400-1:1600, Immunohistochemistry (Paraffin): 1:640-1:2560, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

G.758.4

Isotype :

IgG

Storage :

-20 C

Description :

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.

Immunogen :

Synthetic peptide corresponding to the carboxy terminus of the human CTCF protein

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 10 ul/10^6 cells, Immunocytochemistry: 1:400-1:1600, Immunohistochemistry (Paraffin): 1:640-1:2560, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); Ctcf; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)