ITGA4 Monoclonal Antibody (TA-2) | Invitrogen MA49D7 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ITGA4 Monoclonal Antibody (TA-2)

catalog :

MA49D7

quantity :

500 µg

price :

US 430.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TA-2

reactivity :

human, rat

application :

immunohistochemistry, neutralization, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 5 ug/ml	Brennan F, Smith N, Owen S, Li C, Amjadi P, Green P, et al. Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function. Arthritis Res Ther. 2008;10:R36 pubmed publisher
	Machelska H, Brack A, Mousa S, Schopohl J, Rittner H, Schafer M, et al. Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain. Br J Pharmacol. 2004;142:772-80 pubmed
	Larbi K, Allen A, Tam F, Haskard D, Lobb R, Silva P, et al. VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration. Blood. 2000;96:3601-9 pubmed
	Davies D, Larbi K, Allen A, Sanz M, Weg V, Haskard D, et al. VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. Immunology. 1999;97:150-8 pubmed
	Mastro A, Schlosser D, Grove D, Lincoski C, Pishak S, Gordon S, et al. Lymphocyte subpopulations in lymphoid organs of rats after acute resistance exercise. Med Sci Sports Exerc. 1999;31:74-81 pubmed
	Issekutz T. Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo. J Immunol. 1991;147:4178-84 pubmed
	Issekutz T, Wykretowicz A. Effect of a new monoclonal antibody, TA-2, that inhibits lymphocyte adherence to cytokine stimulated endothelium in the rat. J Immunol. 1991;147:109-16 pubmed

product information

Product Type :

Antibody

Product Name :

ITGA4 Monoclonal Antibody (TA-2)

Catalog # :

MA49D7

Quantity :

500 µg

Price :

US 430.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Neutralization: Assay-dependent

Species :

Human, Rat

Clone :

TA-2

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

Immunogen :

Rat 150 kD alpha4 chain of VLA-4 (CD49d).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Neutralization: Assay-dependent

Aliases :

269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; IA4; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Itga4; Itga4B; ITGA-IV; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha

more info or order :

Invitrogen product webpage