CD44 Monoclonal Antibody (1M7.8.1) | Invitrogen MA4405 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD44 Monoclonal Antibody (1M7.8.1)

catalog :

MA4405

quantity :

500 µg

price :

US 469.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1M7.8.1

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; loading ...; fig 1b	Leng Y, Abdullah A, Wendt M, Calve S. Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis. Matrix Biol. 2019;78-79:236-254 pubmed publisher
flow cytometry; mouse	Randall K, Chan S, Ma C, Fung I, Mei Y, Yabas M, et al. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med. 2011;208:2305-20 pubmed publisher
flow cytometry; mouse; fig 2	Attinger A, MacDonald H, Acha Orbea H. Lymphoid environment limits superantigen and antigen-induced T cell proliferation at high precursor frequency. Eur J Immunol. 2001;31:884-93 pubmed
	Freude K, Saruhanian S, McCauley A, Paterson C, Odette M, Oostenink A, et al. Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells - possibilities and current limitations. World J Stem Cells. 2020;12:1171-1183 pubmed publisher
	Singh P, Deorukhkar A, Venkatesulu B, Li X, Tailor R, Bomalaski J, et al. Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation. Mol Cancer Ther. 2019;18:2381-2393 pubmed publisher
	Voyle R, Beermann F, Lees R, Schumann J, Zimmer J, Held W, et al. Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D. J Exp Med. 2003;197:919-25 pubmed
	Oliferenko S, Paiha K, Harder T, Gerke V, Schwärzler C, Schwarz H, et al. Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton. J Cell Biol. 1999;146:843-54 pubmed
	Pavlovitch J, Hulier E, Rizk Rabin M, Marussig M, Mazier D, Joffret M, et al. Resistance to murine AIDS in offspring of mice infected with LP-BM5. Role of CD8 T cells. J Immunol. 1996;156:4757-63 pubmed
	Chu E, Hobbs M, Wilson C, Romball C, Linsley P, Weigle W. Intervention of CD4+ cell subset shifts and autoimmunity in the BXSB mouse by murine CTLA4Ig. J Immunol. 1996;156:1262-8 pubmed
	Walker P, Ohteki T, Lopez J, MacDonald H, Maryanski J. Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J Immunol. 1995;155:3443-52 pubmed
	Lesley J, Trowbridge I. Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics. 1982;15:313-20 pubmed

product information

Product Type :

Antibody

Product Name :

CD44 Monoclonal Antibody (1M7.8.1)

Catalog # :

MA4405

Quantity :

500 µg

Price :

US 469.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: Assay-dependent, Inhibition Assays: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse

Clone :

1M7.8.1

Isotype :

IgG2b

Storage :

-20°C

Description :

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

Immunogen :

Mouse 80-95 kD lymphocyte surface glycoprotein H-CAM (CD44).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: Assay-dependent, Inhibition Assays: Assay-dependent, Western Blot: Assay-dependent

Aliases :

AU023126; AW121933; AW146109; Bovine CD44; CD44; CD44 antigen; CD44 antigen-like protein; CD44 molecule; CD44 molecule (Indian blood group); CD44 protein; CD44 variant; CD44A; CD44-like protein; CDW44; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; CSPG8; ECMRIII; ECMR-III; Epican; extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; HERMES; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; IN; LHR; Ly-24; lymphocyte antigen 24; lymphocyte surface antigen precursor CD44; MC56; MDU2; MDU3; METAA; MIC4; PGP I; Pgp1; PGP-1; PGPI; PGP-I; Phagocytic glycoprotein 1; phagocytic glycoprotein I; putative Bos taurus CD44; RHAMM; sCD 44; sCD44; soluble CD 44; soluble CD44

more info or order :

Invitrogen product webpage