CD44 Monoclonal Antibody (Hermes-1) | Invitrogen MA4400 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD44 Monoclonal Antibody (Hermes-1)

catalog :

MA4400

quantity :

200 µg

price :

US 469.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

HERMES-1

reactivity :

domestic goat, African green monkey, human, mouse, bovine, domestic sheep, domestic rabbit

application :

immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 28

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; fig 3a	Abdel Mohsen M, Chavez L, Tandon R, Chew G, Deng X, Danesh A, et al. Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. PLoS Pathog. 2016;12:e1005677 pubmed publisher
blocking or activating experiments; human	Dong F, Eibach M, Bartsch J, Dolga A, Schlomann U, Conrad C, et al. The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro Oncol. 2015;17:1474-85 pubmed publisher
immunohistochemistry; mouse	Ferjancic S, Gil Bernabé A, Hill S, Allen P, Richardson P, Sparey T, et al. VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice. Blood. 2013;121:3289-97 pubmed publisher
immunocytochemistry; human; 1:50 immunocytochemistry; African green monkey; 1:50	Lamontagne C, Grandbois M. PKC-induced stiffening of hyaluronan/CD44 linkage; local force measurements on glioma cells. Exp Cell Res. 2008;314:227-36 pubmed
blocking or activating experiments; human	Ellis I, Schor A, Schor S. EGF AND TGF-alpha motogenic activities are mediated by the EGF receptor via distinct matrix-dependent mechanisms. Exp Cell Res. 2007;313:732-41 pubmed
blocking or activating experiments; human	Tsujimura S, Saito K, Kohno K, Tanaka Y. Fragmented hyaluronan induces transcriptional up-regulation of the multidrug resistance-1 gene in CD4+ T cells. J Biol Chem. 2006;281:38089-97 pubmed
	Winkler E, Kim C, Ross J, Garcia J, Gil E, Oh I, et al. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022;375:eabi7377 pubmed publisher
	K xf6 lln L, Salem O, Valli J, Hansen C, McConnell G. Label2label: training a neural network to selectively restore cellular structures in fluorescence microscopy. J Cell Sci. 2022;135: pubmed publisher
	Edwards K, Yao S, Pisano S, Feltracco V, Brüsehafer K, Samanta S, et al. Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models. Cancers (Basel). 2021;13: pubmed publisher
	Kong C, Ordo xf1 ez A, Turner S, Tremaine T, Muter J, Lucas E, et al. Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation. FASEB J. 2021;35:e21336 pubmed publisher
	Ko J, Kim H, Jeong H, Lee H, Oh J. Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis. Cell Rep. 2020;30:3806-3820.e6 pubmed publisher
	Reeves S, Barrow K, Rich L, White M, Shubin N, Chan C, et al. Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases. Front Immunol. 2019;10:3159 pubmed publisher
	Wu M, Chen Y, Kim M, Chang C, Gampala S, Zhang Y, et al. Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Cell Metab. 2019;29:993-1002.e6 pubmed publisher
	Learn G, McClellan P, Knapik D, Cumsky J, Webster Wood V, Anderson J, et al. Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo. J Biomed Mater Res B Appl Biomater. 2019;107:1864-1876 pubmed publisher
	Chiang T, Lin M, Tsai M, Chen C, Jang L, Lee F. ADP-ribosylation factor-like 4A interacts with Robo1 to promote cell migration by regulating Cdc42 activation. Mol Biol Cell. 2019;30:69-81 pubmed publisher
	D Agostino G, Saporito A, Cecchinato V, Silvestri Y, Borgeat A, Anselmi L, et al. Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration. Br J Anaesth. 2018;121:962-968 pubmed publisher
	Tarafder S, Gulko J, Sim K, Yang J, Cook J, Lee C. Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment. Sci Rep. 2018;8:8150 pubmed publisher
	Oyama M, Kariya Y, Kariya Y, Matsumoto K, Kanno M, Yamaguchi Y, et al. Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin. Biochem J. 2018;475:1583-1595 pubmed publisher
	Surendran S, Siddappa G, Mohan A, Hicks W, Jayaprakash V, Mimikos C, et al. Cancer stem cell and its niche in malignant progression of oral potentially malignant disorders. Oral Oncol. 2017;75:140-147 pubmed publisher
	Ozdemir T, Fowler E, Liu S, Harrington D, Witt R, Farach Carson M, et al. Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D. ACS Biomater Sci Eng. 2016;2:2217-2230 pubmed
	Kariya Y, Kariya Y, Saito T, Nishiyama S, Honda T, Tanaka K, et al. Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica. BBA Clin. 2015;3:126-34 pubmed publisher
	Hinek A, Smith A, Cutiongco E, Callahan J, Gripp K, Weksberg R. Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein. Am J Hum Genet. 2000;66:859-72 pubmed
	Maaser K, Wolf K, Klein C, Niggemann B, Zanker K, Brocker E, et al. Functional hierarchy of simultaneously expressed adhesion receptors: integrin alpha2beta1 but not CD44 mediates MV3 melanoma cell migration and matrix reorganization within three-dimensional hyaluronan-containing collagen matrices. Mol Biol Cell. 1999;10:3067-79 pubmed
	Kubens B, Zanker K. Differences in the migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620). Cancer Lett. 1998;131:55-64 pubmed
	Trautmann A, Feuerstein B, Ernst N, Brocker E, Klein C. Heterotypic cell-cell adhesion of human mast cells to fibroblasts. Arch Dermatol Res. 1997;289:194-203 pubmed
	Picker L, de los Toyos J, Telen M, Haynes B, Butcher E. Monoclonal antibodies against the CD44 [In(Lu)-related p80], and Pgp-1 antigens in man recognize the Hermes class of lymphocyte homing receptors. J Immunol. 1989;142:2046-51 pubmed
	Picker L, Nakache M, Butcher E. Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types. J Cell Biol. 1989;109:927-37 pubmed
	Jalkanen S, Bargatze R, Herron L, Butcher E. A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man. Eur J Immunol. 1986;16:1195-202 pubmed

product information

Product Type :

Antibody

Product Name :

CD44 Monoclonal Antibody (Hermes-1)

Catalog # :

MA4400

Quantity :

200 µg

Price :

US 469.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Bovine, Goat, Human, Ovine, Rabbit

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:200, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent

Species :

Bovine, Goat, Human, Ovine, Rabbit

Clone :

Hermes-1

Isotype :

IgG2a

Storage :

-20°C

Description :

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

Immunogen :

80 - 95 kDa lymphocyte surface glycoprotein H-CAM (CD44).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:200, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent

Aliases :

AU023126; AW121933; AW146109; Bovine CD44; CD44; CD44 antigen; CD44 antigen-like protein; CD44 molecule; CD44 molecule (Indian blood group); CD44 protein; CD44 variant; CD44A; CD44-like protein; CDW44; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; CSPG8; ECMRIII; ECMR-III; Epican; extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; HERMES; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; IN; LHR; Ly-24; lymphocyte antigen 24; lymphocyte surface antigen precursor CD44; MC56; MDU2; MDU3; METAA; MIC4; PGP I; Pgp1; PGP-1; PGPI; PGP-I; Phagocytic glycoprotein 1; phagocytic glycoprotein I; putative Bos taurus CD44; RHAMM; sCD 44; sCD44; soluble CD 44; soluble CD44

more info or order :

Invitrogen product webpage