Calmodulin Monoclonal Antibody (6D4) | Invitrogen MA3-918 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Calmodulin Monoclonal Antibody (6D4)

catalog :

MA3-918

quantity :

100 µL

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6D4

reactivity :

Acropora digitifera, Koelliker's sea pansy, human, mouse, rat, chicken, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Ferretti R, Marques M, Khurana T, Santo Neto H. Expression of calcium-buffering proteins in rat intrinsic laryngeal muscles. Physiol Rep. 2015;3: pubmed publisher
immunocytochemistry; mouse; 1:100	Bazwinsky Wutschke I, Muhlbauer E, Albrecht E, Peschke E. Calcium-signaling components in rat insulinoma ?-cells (INS-1) and pancreatic islets are differentially influenced by melatonin. J Pineal Res. 2014;56:439-49 pubmed publisher
immunohistochemistry; rat; 1:50 western blot; rat; 1:1000	Bazwinsky Wutschke I, Wolgast S, Muhlbauer E, Peschke E. Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma beta-cells (INS-1). Histochem Cell Biol. 2010;134:115-27 pubmed publisher
western blot; Koelliker's sea pansy; 1:1000	Morita M, Kitamura M, Nakajima A, Sri Susilo E, Takemura A, Okuno M. Regulation of sperm flagellar motility activation and chemotaxis caused by egg-derived substance(s) in sea cucumber. Cell Motil Cytoskeleton. 2009;66:202-14 pubmed publisher
western blot; Acropora digitifera; 1:1000	Morita M, Iguchi A, Takemura A. Roles of calmodulin and calcium/calmodulin-dependent protein kinase in flagellar motility regulation in the coral Acropora digitifera. Mar Biotechnol (NY). 2009;11:118-23 pubmed publisher
	Glover L, Heffron J, Ohlendieck K. Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle. J Appl Physiol (1985). 2004;96:11-8 pubmed
	Hulen D, Baron A, Salisbury J, Clarke M. Production and specificity of monoclonal antibodies against calmodulin from Dictyostelium discoideum. Cell Motil Cytoskeleton. 1991;18:113-22 pubmed
	Coling D, Salisbury J. Characterization of the calcium-binding contractile protein centrin from Tetraselmis striata (Pleurastrophyceae). J Protozool. 1992;39:385-91 pubmed
	Zhu Q, Clarke M. Association of calmodulin and an unconventional myosin with the contractile vacuole complex of Dictyostelium discoideum. J Cell Biol. 1992;118:347-58 pubmed

image

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product information

Product Type :

Antibody

Product Name :

Calmodulin Monoclonal Antibody (6D4)

Catalog # :

MA3-918

Quantity :

100 µL

Price :

US 375.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Bacteria, Bovine, Chicken, Human, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:250, Western Blot: 1:2,000

Species :

Bacteria, Bovine, Chicken, Human, Rat

Clone :

6D4

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Calmodulin is a small, highly conserved calcium binding protein found in all eukaryotic cells. With the capacity to bind up to four calcium ions, this 17 kDa protein acts as an important intracellular receptor for regulatory calcium signals. As it binds calcium, calmodulin undergoes conformational changes which can increase its affinity for target proteins. It acts both directly, through interaction with key target enzymes, and indirectly, via specific kinases. Studies have found that calmodulin participates in the regulation of several biological processes including energy and biosynthetic metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of both cAMP and calcium concentrations. Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.

Immunogen :

Calmodulin purified from Dictyostelium discoideum.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:250, Western Blot: 1:2,000

Aliases :

1500001E21Rik; 2310037J09Rik; AI256814; AI327027; AI461935; AI649108; AL024000; AL024017; AY314008; calcium binding gene, DD112; calcium-binding protein Dd112; CALM; CALM 1; CALM1; CALM2; Calm3; Calm4; Calm5; CALML2; Calmodulin; calmodulin 1; calmodulin 1 (phosphorylase kinase, delta); calmodulin 2; calmodulin 2 (phosphorylase kinase, delta); calmodulin 3; calmodulin 3 (phosphorylase kinase, delta); calmodulin 4; calmodulin 5; Calmodulin III; calmodulin-1; Calmodulin-2; calmodulin-3; Calmodulin-4; calmodulin-like; calmodulin-like protein; calmodulin-like protein (neoCaM); caM; CAM1; Cam2; CAM3; CaMA; Camb; CamC; CaMI; CAMII; CAMIII; CPVT4; DD112; DD132; epididymis secretory protein Li 72; HEL-S-72; hypothetical protein; LP7057 protein; LQT14; LQT15; MGC128137 protein; neo-calmodulin; NeoCaM; PHKD; PHKD2; PHKD3; phosphorylase kinase delta; phosphorylase kinase subunit delta; phosphorylase kinase, delta subunit; prepro-calmodulin 1; prepro-calmodulin 2; prepro-calmodulin 3; R75142; RNCAMIII; Scarf; Scarf2; similar to calmodulin; skin calmodulin-related factor

more info or order :

Invitrogen product webpage