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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SERCA2 ATPase Monoclonal Antibody (IID8)
catalog :
MA3-910
quantity :
100 µL
price :
US 399.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
IID8
reactivity :
hamsters, guinea pig, human, mouse, rat, dogs, chicken, bovine, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 145
| Published Application/Species/Sample/Dilution | Reference |
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| Gustavo Vazquez Jimenez J, Chavez Reyes J, Romero Garcia T, Zarain Herzberg A, Valdes Flores J, Manuel Galindo Rosales J, et al. Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. Cell Signal. 2016;28:53-9 pubmed publisher
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| Ahmad F, Shen W, Vandeput F, Szabo Fresnais N, Krall J, Degerman E, et al. Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2. J Biol Chem. 2015;290:6763-76 pubmed publisher
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| Leanza L, O Reilly P, Doyle A, Venturini E, Zoratti M, Szegezdi E, et al. Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines. Curr Pharm Des. 2014;20:189-200 pubmed
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| Leanza L, Zoratti M, Gulbins E, Szabo I. Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels. Curr Med Chem. 2012;19:5394-404 pubmed
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| Grice D, Vetter I, Faddy H, Kenny P, Roberts Thomson S, Monteith G. Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J Biol Chem. 2010;285:37458-66 pubmed publisher
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| Jorge L, Rodrigues B, Rosa K, Malfitano C, Loureiro T, Medeiros A, et al. Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality. Eur Heart J. 2011;32:904-12 pubmed publisher
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| Lee S, Grafweg S, Schneider T, Jimenez M, Giacobino J, Ghanem A, et al. Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy. Physiol Res. 2010;59:679-89 pubmed
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| Majerczak J, Karasinski J, Zoladz J. Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle. J Physiol Pharmacol. 2008;59:589-602 pubmed
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| Donoghue P, Doran P, Wynne K, Pedersen K, Dunn M, Ohlendieck K. Proteomic profiling of chronic low-frequency stimulated fast muscle. Proteomics. 2007;7:3417-30 pubmed
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| Sepulveda M, Berrocal M, Marcos D, Wuytack F, Mata A. Functional and immunocytochemical evidence for the expression and localization of the secretory pathway Ca2+-ATPase isoform 1 (SPCA1) in cerebellum relative to other Ca2+ pumps. J Neurochem. 2007;103:1009-18 pubmed
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| Aoki T, Hagiwara H, Matsuzaki T, Suzuki T, Takata K. Internalization of caveolae and their relationship with endosomes in cultured human and mouse endothelial cells. Anat Sci Int. 2007;82:82-97 pubmed
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| Armoundas A, Rose J, Aggarwal R, Stuyvers B, O ROURKE B, Kass D, et al. Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol. 2007;292:H1607-18 pubmed
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| Rodriguez P, Mitton B, Waggoner J, Kranias E. Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function. J Biol Chem. 2006;281:38599-608 pubmed
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| Okkenhaug H, Weylandt K, Carmena D, Wells D, Higgins C, Sardini A. The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus. FASEB J. 2006;20:2390-2 pubmed
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| Satoh K, Hata M, Takahara S, Tsuzaki H, Yokota H, Akatsu H, et al. A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes. Brain Res. 2006;1108:19-27 pubmed
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| Harada K, Lin H, Endo Y, Fujishiro N, Sakamoto Y, Inoue M. Subunit composition and role of Na+,K+-ATPases in ventricular myocytes. J Physiol Sci. 2006;56:113-21 pubmed
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| Kogler H, Schott P, Toischer K, Milting H, Van P, Kohlhaas M, et al. Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression. Circulation. 2006;113:2724-32 pubmed
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| Chaabane C, Corvazier E, Bredoux R, Dally S, Raies A, Villemain A, et al. Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress. Biochem Biophys Res Commun. 2006;345:1377-85 pubmed
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| Nurden P, Debili N, Vainchenker W, Bobe R, Bredoux R, Corvazier E, et al. Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia. Blood. 2006;108:2587-95 pubmed
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| Xu S, Ying J, Jiang B, Guo W, Adachi T, Sharov V, et al. Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. Am J Physiol Heart Circ Physiol. 2006;290:H2220-7 pubmed
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| Dremina E, Sharov V, SCHONEICH C. Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivation. Biochemistry. 2006;45:175-84 pubmed
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| Dolnikov K, Shilkrut M, Zeevi Levin N, Gerecht Nir S, Amit M, Danon A, et al. Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction. Stem Cells. 2006;24:236-45 pubmed
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| Kettlewell S, Most P, Currie S, Koch W, Smith G. S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. J Mol Cell Cardiol. 2005;39:900-10 pubmed
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| Acevedo L, Rivero J. New insights into skeletal muscle fibre types in the dog with particular focus towards hybrid myosin phenotypes. Cell Tissue Res. 2006;323:283-303 pubmed
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| Donoghue P, Doran P, Dowling P, Ohlendieck K. Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation. Biochim Biophys Acta. 2005;1752:166-76 pubmed
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| Sepulveda M, Hidalgo Sanchez M, Mata A. A developmental profile of the levels of calcium pumps in chick cerebellum. J Neurochem. 2005;95:673-83 pubmed
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| de Meis L, Oliveira G, Arruda A, Santos R, Costa R, Benchimol M. The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase. IUBMB Life. 2005;57:337-45 pubmed
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| Kimura M, Cao X, Aviv A. Calcium adaptation to sodium pump inhibition in a human megakaryocytic cell line. Am J Physiol Cell Physiol. 2005;289:C891-7 pubmed
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| Albrecht C, McVey J, Elliott J, Sardini A, Kasza I, Mumford A, et al. A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood. 2005;106:542-9 pubmed
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| Brini M, Miuzzo M, Pierobon N, Negro A, Sorgato M. The prion protein and its paralogue Doppel affect calcium signaling in Chinese hamster ovary cells. Mol Biol Cell. 2005;16:2799-808 pubmed
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| Deschamps A, Yarbrough W, Squires C, Allen R, McClister D, Dowdy K, et al. Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity. Circulation. 2005;111:1166-74 pubmed
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| Nguyen T, Rubinstein N, Vijayasarathy C, Rome L, Kaiser L, Shrager J, et al. Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm. J Appl Physiol (1985). 2005;98:2004-10 pubmed
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| Most P, Boerries M, Eicher C, Schweda C, Völkers M, Wedel T, et al. Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes. J Cell Sci. 2005;118:421-31 pubmed
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| Kaliman P, Catalucci D, Lam J, Kondo R, Gutiérrez J, Reddy S, et al. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005;280:8016-21 pubmed
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| Nakayama M, Yan X, Price R, Borg T, Ito K, Sanbe A, et al. Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction. Am J Physiol Heart Circ Physiol. 2005;288:H317-27 pubmed
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Foster D, Rucker J, Marban E. Is Kir6.1 a subunit of mitoK(ATP)?. Biochem Biophys Res Commun. 2008;366:649-56 pubmed
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Miyauchi Y, Daiho T, Yamasaki K, Takahashi H, Ishida Yamamoto A, Danko S, et al. Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease. J Biol Chem. 2006;281:22882-95 pubmed
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Lee W, Robinson J, Holman N, McCall M, Roberts Thomson S, Monteith G. Antisense-mediated Inhibition of the plasma membrane calcium-ATPase suppresses proliferation of MCF-7 cells. J Biol Chem. 2005;280:27076-84 pubmed
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Vanoevelen J, Dode L, Van Baelen K, Fairclough R, Missiaen L, Raeymaekers L, et al. The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions. J Biol Chem. 2005;280:22800-8 pubmed
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Quiroz Rothe E, Rivero J. Coordinated expression of myosin heavy chains, metabolic enzymes, and morphological features of porcine skeletal muscle fiber types. Microsc Res Tech. 2004;65:43-61 pubmed
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Chauvet V, Tian X, Husson H, Grimm D, Wang T, Hiesberger T, et al. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest. 2004;114:1433-43 pubmed
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Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, et al. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest. 2004;113:727-36 pubmed
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Waggoner J, Huffman J, Griffith B, Jones L, Mahaney J. Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells. Protein Expr Purif. 2004;34:56-67 pubmed
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Huang Y, Walker K, Hanley F, Narula J, Houser S, Tulenko T. Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet. Circulation. 2004;109:97-102 pubmed
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Kjellgren D, Ryan M, Ohlendieck K, Thornell L, Pedrosa Domellöf F. Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles. Invest Ophthalmol Vis Sci. 2003;44:5057-62 pubmed
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Glover L, Heffron J, Ohlendieck K. Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle. J Appl Physiol (1985). 2004;96:11-8 pubmed
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del Valle Rodriguez A, Lopez Barneo J, Ureña J. Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx. EMBO J. 2003;22:4337-45 pubmed
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de Meis L. Brown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity. J Biol Chem. 2003;278:41856-61 pubmed
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Arruda A, da Silva W, Carvalho D, de Meis L. Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase. Biochem J. 2003;375:753-60 pubmed
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Mulvey C, Ohlendieck K. Use of continuous-elution gel electrophoresis as a preparative tool for blot overlay analysis. Anal Biochem. 2003;319:122-30 pubmed
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Kim D, Zhu J, Kozyak B, Burkman J, Rubinstein N, Lankford E, et al. Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema. Respir Res. 2003;4:1 pubmed
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O Reilly C, Pette D, Ohlendieck K. Increased expression of the nicotinic acetylcholine receptor in stimulated muscle. Biochem Biophys Res Commun. 2003;300:585-91 pubmed
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Wamhoff B, Bowles D, Dietz N, Hu Q, Sturek M. Exercise training attenuates coronary smooth muscle phenotypic modulation and nuclear Ca2+ signaling. Am J Physiol Heart Circ Physiol. 2002;283:H2397-410 pubmed
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Min J, Sullivan M, Yan X, Feng X, Chu V, Wang J, et al. Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2002;283:H2466-71 pubmed
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Glover L, Quinn S, Ryan M, Pette D, Ohlendieck K. Supramolecular calsequestrin complex. Eur J Biochem. 2002;269:4607-16 pubmed
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Adachi T, Matsui R, Xu S, Kirber M, Lazar H, Sharov V, et al. Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation. Circ Res. 2002;90:1114-21 pubmed
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Tapper H, Furuya W, Grinstein S. Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules. J Immunol. 2002;168:5287-96 pubmed
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Musa H, Lei M, Honjo H, Jones S, Dobrzynski H, Lancaster M, et al. Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node. J Histochem Cytochem. 2002;50:311-24 pubmed
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Ennis I, Li R, Murphy A, Marban E, Nuss H. Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility. J Clin Invest. 2002;109:393-400 pubmed
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Gruijthuijsen Y, Casarosa P, Kaptein S, Broers J, Leurs R, Bruggeman C, et al. The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion. J Virol. 2002;76:1328-38 pubmed
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Lockwich T, Singh B, Liu X, Ambudkar I. Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association. J Biol Chem. 2001;276:42401-8 pubmed
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Harmon S, Froemming G, Leisner E, Pette D, Ohlendieck K. Low-frequency stimulation of fast muscle affects the abundance of Ca(2+)-ATPase but not its oligomeric status. J Appl Physiol (1985). 2001;90:371-9 pubmed
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Dode L, Van Baelen K, Wuytack F, Dean W. Low temperature molecular adaptation of the skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA 1) in the wood frog (Rana sylvatica). J Biol Chem. 2001;276:3911-9 pubmed
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Froemming G, Murray B, Harmon S, Pette D, Ohlendieck K. Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers. Biochim Biophys Acta. 2000;1466:151-68 pubmed
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Patterson R, van Rossum D, Gill D. Store-operated Ca2+ entry: evidence for a secretion-like coupling model. Cell. 1999;98:487-99 pubmed
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Ueda H, Shimokawa M, Yamamoto M, Kameda N, Mizusawa H, Baba T, et al. Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy. J Neurol Sci. 1999;162:38-50 pubmed
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Misquitta C, Sing A, Grover A. Control of sarcoplasmic/endoplasmic-reticulum Ca2+ pump expression in cardiac and smooth muscle. Biochem J. 1999;338 ( Pt 1):167-73 pubmed
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Xu K, Huso D, Dawson T, Bredt D, Becker L. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci U S A. 1999;96:657-62 pubmed
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Horiguchi M, Kimura M, Lytton J, Skurnick J, Nash F, Awad G, et al. Ca2+ in the dense tubules: a model of platelet Ca2+ load. Hypertension. 1998;31:595-602 pubmed
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Lee M, Xu X, Zeng W, Diaz J, Kuo T, Wuytack F, et al. Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of [Ca2+]i waves. J Biol Chem. 1997;272:15771-6 pubmed
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De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, et al. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J Biol Chem. 1997;272:3590-8 pubmed
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Negash S, Chen L, Bigelow D, Squier T. Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes. Biochemistry. 1996;35:11247-59 pubmed
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Sharp A, McPherson P, Dawson T, Aoki C, Campbell K, Snyder S. Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain. J Neurosci. 1993;13:3051-63 pubmed
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Knudson C, Stang K, Jorgensen A, Campbell K. Biochemical characterization of ultrastructural localization of a major junctional sarcoplasmic reticulum glycoprotein (triadin). J Biol Chem. 1993;268:12637-45 pubmed
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Jorgensen A, Shen A, Arnold W, McPherson P, Campbell K. The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle. J Cell Biol. 1993;120:969-80 pubmed
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Magnier C, Bredoux R, Kovacs T, Quarck R, Papp B, Corvazier E, et al. Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines. Biochem J. 1994;297 ( Pt 2):343-50 pubmed
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Hu P, Yin C, Zhang K, Wright L, Nixon T, Wechsler A, et al. Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching. J Biol Chem. 1995;270:11619-22 pubmed
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Jorgensen A, Arnold W, Pepper D, Kahl S, Mandel F, Campbell K. A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study. Cell Motil Cytoskeleton. 1988;9:164-74 pubmed
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Briggs F, Lee K, Feher J, Wechsler A, Ohlendieck K, Campbell K. Ca-ATPase isozyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle. FEBS Lett. 1990;259:269-72 pubmed
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Movsesian M, Leveille C, Krall J, Colyer J, Wang J, Campbell K. Identification and characterization of proteins in sarcoplasmic reticulum from normal and failing human left ventricles. J Mol Cell Cardiol. 1990;22:1477-85 pubmed
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Ohlendieck K, Ervasti J, Snook J, Campbell K. Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma. J Cell Biol. 1991;112:135-48 pubmed
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Spencer G, Yu X, Khan I, Grover A. Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues. Biochim Biophys Acta. 1991;1063:15-20 pubmed
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Plessers L, Eggermont J, Wuytack F, Casteels R. A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons. J Neurosci. 1991;11:650-6 pubmed
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Molnar E, Seidler N, Jona I, Martonosi A. The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules. Biochim Biophys Acta. 1990;1023:147-67 pubmed
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Ohlendieck K, Briggs F, Lee K, Wechsler A, Campbell K. Analysis of excitation-contraction-coupling components in chronically stimulated canine skeletal muscle. Eur J Biochem. 1991;202:739-47 pubmed
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Molnar E, Varga S, Jona I, Seidler N, Martonosi A. Immunological relatedness of the sarcoplasmic reticulum Ca(2+)-ATPase and the Na+,K(+)-ATPase. Biochim Biophys Acta. 1992;1103:281-95 pubmed
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image
image 1 :
Immunofluorescent analysis of SERCA2 ATPase using SERCA2 ATPase Monoclonal antibody (IID8) (Product# MA3-910) shows staining in A549 cells. SERCA2 ATPase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing SERCA2 ATPase (Product# MA3-910) at a dilution of 1:100-1:200 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
product information
Product Type :
Antibody
Product Name :
SERCA2 ATPase Monoclonal Antibody (IID8)
Catalog # :
MA3-910
Quantity :
100 µL
Price :
US 399.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Bovine, Canine, Human, Mouse, Porcine, Rabbit, Rat
Applications :
Flow Cytometry: 1 µg / 10^6 cells, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 1 µg/mL, Western Blot: 1:500-1:5,000
Species :
Bovine, Canine, Human, Mouse, Porcine, Rabbit, Rat
Clone :
IID8
Isotype :
IgG1
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen :
Purified canine cardiac sarcoplasmic reticulum.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg / 10^6 cells, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 1 µg/mL, Western Blot: 1:500-1:5,000
Aliases :
9530097L16Rik; ATP2; Atp2a2; ATP2B; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Ca(2+)-transport ATPase class 3; calcium ATPase; calcium pump 2; calcium-ATPase (EC 3.6.1.3); calcium-transporting ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; D5Wsu150e; DAR; DD; endoplasmic reticulum class 1/2 Ca(2+) ATPase; mKIAA4195; putative SERCA isoform; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; sarcoplasmic reticulum Ca2+-transport ATPase isoform; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2; SERCA; SERCA ATPase; SERCA2; Serca2a; SERCA2B; SercaII; SR Ca(2+)-ATPase 2; unnamed protein product
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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