Phosphatidylinositol 4,5-bisphosphate Monoclonal Antibody (2C11)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phosphatidylinositol 4,5-bisphosphate Monoclonal Antibody (2C11)

catalog :

MA3-500

quantity :

100 uL

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2C11

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 7

Reference
Toh E, Baryalai P, Nadeem A, Aung K, Chen S, Persson K, et al. Bacterial protein MakA causes suppression of tumour cell proliferation via inhibition of PIP5K1α/Akt signalling. Cell Death Dis. 2022;13:1024 pubmed publisher
Lin T, Kuo H, Wu Y, Pan T, Yih L. Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization. Cell Div. 2019;14:9 pubmed publisher
Effertz T, Becker L, Peng A, Ricci A. Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation. J Neurosci. 2017;37:11632-11646 pubmed publisher
Chung S, Ercan B, Roy A, Webster T. Addition of Selenium Nanoparticles to Electrospun Silk Scaffold Improves the Mammalian Cell Activity While Reducing Bacterial Growth. Front Physiol. 2016;7:297 pubmed publisher
Haberzettl P, Vladykovskaya E, Srivastava S, Bhatnagar A. Role of endoplasmic reticulum stress in acrolein-induced endothelial activation. Toxicol Appl Pharmacol. 2009;234:14-24 pubmed publisher
Osborne S, Thomas C, Gschmeissner S, Schiavo G. Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J Cell Sci. 2001;114:2501-11 pubmed
Thomas C, Steel J, Prestwich G, Schiavo G. Generation of phosphatidylinositol-specific antibodies and their characterization. Biochem Soc Trans. 1999;27:648-52 pubmed

product information

Product Type :

Antibody

Product Name :

Phosphatidylinositol 4,5-bisphosphate Monoclonal Antibody (2C11)

Catalog # :

MA3-500

Quantity :

100 uL

Price :

US 471.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Chemical

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Species :

Chemical

Clone :

2C11

Isotype :

IgM

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Phosphatidylinositol 4,5-bisphosphate or PIP2 is an important second messenger for a number of signaling processes. When certain extracellular signals are received, Phosphilipase C cleaves phosphatidylinositol into DAG and PIP2. PIP2 has been shown to interact with actin structural proteins including profiling, gelsolin, and cofilin, and demonstrates regulatory function of actin polymerization. It has also been shown to regulate vesicular transport by interacting with proteins like ADP-ribosylation factor and phospholipase D. PIP2 has also been shown to significantly affect intracellular calcium concentrations, which also regulate a variety of activities.

Immunogen :

Liposomes (prepared in PBS with lipid A, phosphatidylcholine (PC) and cholesterol) containing synthetic di-palmitoyl PtdIns(4,5)P2.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Aliases :

C45H85O19P3; PIP2