CHRM2 Monoclonal Antibody (31-1D1) | Invitrogen MA3-044 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CHRM2 Monoclonal Antibody (31-1D1)

catalog :

MA3-044

quantity :

250 µL

price :

US 399.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

31-1D1

reactivity :

human, mouse, rat, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:3000	Chen J, Wen J, Cai W. Smooth muscle adaptation and recovery of contractility after massive small bowel resection in rats. Exp Biol Med (Maywood). 2012;237:578-84 pubmed publisher
immunoprecipitation; human western blot; human; 1:1000	Ma A, Dong J, Ma D, Wells J. Cleavage-resistant fusion proteins of the M(2) muscarinic receptor and G?(i1). Homotropic and heterotropic effects in the binding of ligands. Biochim Biophys Acta. 2011;1810:592-602 pubmed publisher
western blot; human; 1:1000	Colozo A, Park P, Sum C, Pisterzi L, Wells J. Cholesterol as a determinant of cooperativity in the M2 muscarinic cholinergic receptor. Biochem Pharmacol. 2007;74:236-55 pubmed
	Wang P, Luthin G, Ruggieri M. Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J Pharmacol Exp Ther. 1995;273:959-66 pubmed
	Wreggett K, Wells J. Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J Biol Chem. 1995;270:22488-99 pubmed
	Luetje C, Brumwell C, Norman M, Peterson G, Schimerlik M, Nathanson N. Isolation and characterization of monoclonal antibodies specific for the cardiac muscarinic acetylcholine receptor. Biochemistry. 1987;26:6892-6 pubmed

product information

Product Type :

Antibody

Product Name :

CHRM2 Monoclonal Antibody (31-1D1)

Catalog # :

MA3-044

Quantity :

250 µL

Price :

US 399.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Porcine, Rat

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Species :

Human, Mouse, Porcine, Rat

Clone :

31-1D1

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.

Immunogen :

Purified porcine cardiac m2 muscarinic acetylcholine receptor.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Aliases :

7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; AChR-M2; Acm2; cardiac muscarinic acetylcholine receptor; cholinergic receptor; cholinergic receptor muscarinic 2; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; Chrm2; Chrm-2; FLJ43243; HM2; M2; M2 muscarinic acetylcholine receptor; m2AChR; M2-mAChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; muscarinic acetylcholine receptor m2; muscarinic M2 receptor; muscarinic receptor m2; unnamed protein product

more info or order :

Invitrogen product webpage