Huntingtin Monoclonal Antibody (1HU-4C8) | Invitrogen MA3-040 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Huntingtin Monoclonal Antibody (1HU-4C8)

catalog :

MA3-040

quantity :

50 uL

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1HU-4C8

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Gerson J, Safren N, Fischer S, Patel R, Crowley E, Welday J, et al. Ubiquilin-2 differentially regulates polyglutamine disease proteins. Hum Mol Genet. 2020;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Huntingtin Monoclonal Antibody (1HU-4C8)

Catalog # :

MA3-040

Quantity :

50 uL

Price :

US 491.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000-1:2,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

1HU-4C8

Isotype :

IgG1, kappa

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.

Immunogen :

Huntingtin fragment from aa 181 to 810

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000-1:2,000

Aliases :

AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4