GSK3 alpha/beta Monoclonal Antibody (4G-1E) | Invitrogen MA3-038 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GSK3 alpha/beta Monoclonal Antibody (4G-1E)

catalog :

MA3-038

quantity :

50 uL

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G-1E

reactivity :

human, mouse, rat, dogs, fruit fly

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, RNA immunoprecipitation

citations: 3

Reference
Lin K, Wang W, Lin C, Rastegari E, Su Y, Chang Y, et al. Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. Nat Commun. 2020;11:3147 pubmed publisher
Cao Y, Lv W, Ding W, Li J. Sevoflurane inhibits the proliferation and invasion of hepatocellular carcinoma cells through regulating the PTEN/Akt/GSK‑3β/β‑catenin signaling pathway by downregulating miR‑25‑3p. Int J Mol Med. 2020;46:97-106 pubmed publisher
Liang W, Wong C, Liang P, Shi M, Cao Y, Rao S, et al. Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway. Genome Biol. 2019;20:84 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GSK3 alpha/beta Monoclonal Antibody (4G-1E)

Catalog # :

MA3-038

Quantity :

50 uL

Price :

US 491.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Canine, Drosophila, Human, Mouse, Non-human primate, Rat

Applications :

Flow Cytometry: 1:100, Immunocytochemistry: 1:1,000, Immunoprecipitation: Assay-Dependent, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Species :

Canine, Drosophila, Human, Mouse, Non-human primate, Rat

Clone :

4G-1E

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Glycogen synthase kinase-3 (GSK3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3's substrate specificity is unique in that phosphorylation of the substrate only occurs if a phosphoserine or phosphotyrosine is present - four residues C-terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, GSK3 alpha and GSK3 beta, and they are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3alpha) by protein kinase B (PKB) causes its inactivation and is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer's disease.

Immunogen :

Synthetic peptide corresponding to residues 203-219 of drosophila GSK-3 coupled to ovalbumin: KQLLHGEPNVSYICSRY

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100, Immunocytochemistry: 1:1,000, Immunoprecipitation: Assay-Dependent, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Aliases :

2700086H06Rik; 7330414F15Rik; 8430431H08Rik; C86142; FA; factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 alpha; Glycogen synthase kinase-3 beta; GSK3; GSK-3; GSK-3 alpha; GSK-3 beta; Gsk3a; gsk-3-alpha; Gsk3b; GSK-3beta; GSK3beta isoform; serine/threonine-protein kinase GSK3A; Serine/threonine-protein kinase GSK3B