HSP90 alpha Monoclonal Antibody (3G3) | Invitrogen MA3-011 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HSP90 alpha Monoclonal Antibody (3G3)

catalog :

MA3-011

quantity :

400 µL

price :

US 400

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G3

reactivity :

human, mouse, rat, chicken

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 17

Reference
Rajapaksa G, Nikolos F, Bado I, Clarke R, Gustafsson J, Thomas C. ERÎ² decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway. Oncogene. 2015;34:4130-41 pubmed publisher
Belova L, Brickley D, Ky B, Sharma S, Conzen S. Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. J Biol Chem. 2008;283:18821-31 pubmed publisher
Corboy M, Thomas P, Wigley W. Aggresome formation. Methods Mol Biol. 2005;301:305-27 pubmed
Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H. The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor. Mol Endocrinol. 2005;19:1110-24 pubmed
Squires E, Sueyoshi T, Negishi M. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem. 2004;279:49307-14 pubmed
Galigniana M, Harrell J, Housley P, Patterson C, Fisher S, Pratt W. Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. Brain Res Mol Brain Res. 2004;123:27-36 pubmed
Harrell J, Kurek I, Breiman A, Radanyi C, Renoir J, Pratt W, et al. All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells. Biochemistry. 2002;41:5581-7 pubmed
Corboy M, Thomas P, Wigley W. CFTR degradation and aggregation. Methods Mol Med. 2002;70:277-94 pubmed
Piwien Pilipuk G, Kanelakis K, Ghini A, Lantos C, Litwack G, Burton G, et al. Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxidoprogesterone. Biochim Biophys Acta. 2002;1589:31-48 pubmed
Waxman L, Whitney M, Pollok B, Kuo L, Darke P. Host cell factor requirement for hepatitis C virus enzyme maturation. Proc Natl Acad Sci U S A. 2001;98:13931-5 pubmed
Murphy P, Kanelakis K, Galigniana M, Morishima Y, Pratt W. Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate. J Biol Chem. 2001;276:30092-8 pubmed
Kazlauskas A, Sundstrom S, Poellinger L, Pongratz I. The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol Cell Biol. 2001;21:2594-607 pubmed
Hu J, Anselmo D. In vitro reconstitution of a functional duck hepatitis B virus reverse transcriptase: posttranslational activation by Hsp90. J Virol. 2000;74:11447-55 pubmed
Kazlauskas A, Poellinger L, Pongratz I. The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem. 2000;275:41317-24 pubmed
Silverstein A, Galigniana M, Kanelakis K, Radanyi C, Renoir J, Pratt W. Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein. J Biol Chem. 1999;274:36980-6 pubmed
Oakley R, Jewell C, Yudt M, Bofetiado D, Cidlowski J. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem. 1999;274:27857-66 pubmed
Soga S, Neckers L, Schulte T, Shiotsu Y, Akasaka K, Narumi H, et al. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. Cancer Res. 1999;59:2931-8 pubmed

product information

Product Type :

Antibody

Product Name :

HSP90 alpha Monoclonal Antibody (3G3)

Catalog # :

MA3-011

Quantity :

400 µL

Price :

US 400

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Chicken, Fish, Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: 1:500-1:1,000, Western Blot: 1:200-1:1,000

Species :

Chicken, Fish, Human, Mouse, Non-human primate, Rat

Clone :

3G3

Isotype :

IgM

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.

Immunogen :

Purified mouse HSP90.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: 1:500-1:1,000, Western Blot: 1:200-1:1,000

Aliases :

86kDa; 89kDa; 90-kDa heat shock protein; 90-kDa heat shock protein alpha; akineto; AL024080; AL024147; EL52; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; fb17b01; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90; heat shock protein 90 alpha family class A member 1; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1; heat shock protein 90-alpha 1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein alpha; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-alpha 1; heat shock protein HSP90 alpha; heat shock protein hsp90alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; HEL-S-65p; HSP; HSP 86; HSP 90 alpha; hsp4; HSP86; Hsp86-1; Hsp89; HSP89A; HSP90; hsp90a; hsp90a protein; hsp90a.1; hsp90aa1; hsp90aa1.1; hsp90alpha; HSP90N; HSPC1; Hspca; HSPCA protein; HSPCAL1; HSPCAL4; HSPN; hypothetical protein; LAP2; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; renal carcinoma antigen NY-REN-38; slo; sloth; TSTA; Tumor-specific transplantation 86 kDa antigen; wu:fb17b01; zgc:86652