ITGB1 Monoclonal Antibody (TS2/16) | Invitrogen MA2910 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ITGB1 Monoclonal Antibody (TS2/16)

catalog :

MA2910

quantity :

200 µg

price :

US 469.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TS2/16

reactivity :

human, mouse, domestic sheep

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 34

Published Application/Species/Sample/Dilution	Reference
flow cytometry; domestic sheep; loading ...; fig 2b	Hunka J, Riley J, Debes G. Approaches to overcome flow cytometry limitations in the analysis of cells from veterinary relevant species. BMC Vet Res. 2020;16:83 pubmed publisher
blocking or activating experiments; human; 20 ug/ml; fig 1	HÃ¸ye A, Couchman J, Wewer U, Yoneda A. The Phosphorylation and Distribution of Cortactin Downstream of Integrin Î±9Î²1 Affects Cancer Cell Behaviour. Sci Rep. 2016;6:28529 pubmed publisher
flow cytometry; human; loading ...; fig 2a	Jürets A, Le Bras M, Staffler G, Stein G, Leitner L, Neuhofer A, et al. Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage. PLoS ONE. 2016;11:e0148333 pubmed publisher
immunocytochemistry; human western blot; human	Beaty B, Sharma V, Bravo Cordero J, Simpson M, Eddy R, Koleske A, et al. ?1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Mol Biol Cell. 2013;24:1661-75, S1-11 pubmed publisher
flow cytometry; human western blot; human	Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, et al. TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner. J Immunol. 2010;184:4761-9 pubmed publisher
blocking or activating experiments; human	Tanaka M, Abe T, Hara Y. Roles of focal adhesions and fibronectin-mediated cohesion in proliferation of confluent fibroblasts. J Cell Physiol. 2009;219:194-201 pubmed publisher
immunohistochemistry; human	Wijnhoven J, Hafmans T, Dekhuijzen P. Distribution of costameric proteins in the diaphragm of patients with chronic obstructive pulmonary disease. Respiration. 2006;73:529-37 pubmed
blocking or activating experiments; mouse	Jones N, Peak J, Brader S, Eccles S, Katan M. PLCgamma1 is essential for early events in integrin signalling required for cell motility. J Cell Sci. 2005;118:2695-706 pubmed
	Shanthi K, Fischer D, Sharma A, Kiviniemi A, Kaakinen M, Vainio S, et al. Human Adult Astrocyte Extracellular Vesicle Transcriptomics Study Identifies Specific RNAs Which Are Preferentially Secreted as EV Luminal Cargo. Genes (Basel). 2023;14: pubmed publisher
	Erami Z, Heitz S, Bresnick A, Backer J. PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation. Mol Biol Cell. 2019;30:2367-2376 pubmed publisher
	García Diaz B, Bachelin C, Coulpier F, Gerschenfeld G, Deboux C, Zujovic V, et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol. 2019;: pubmed publisher
	Machado Pineda Y, Cardeñes B, Reyes R, López Martín S, Toribio V, Sánchez Organero P, et al. CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17. Front Immunol. 2018;9:2474 pubmed publisher
	Myllymäki S, Kämäräinen U, Liu X, Cruz S, Miettinen S, Vuorela M, et al. Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization. Mol Cell Proteomics. 2019;18:277-293 pubmed publisher
	Alejo A, Matamoros T, Guerra M, Andres G. A Proteomic Atlas of the African Swine Fever Virus Particle. J Virol. 2018;92: pubmed publisher
	Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, et al. IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. elife. 2018;7: pubmed publisher
	Parikh Z, Tripathi A, Pillai P. Differential Regulation of MeCP2 Phosphorylation by Laminin in Oligodendrocytes. J Mol Neurosci. 2017;62:309-317 pubmed publisher
	Mattila J, Beaino W, Maiello P, Coleman M, White A, Scanga C, et al. Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin ?4?1-Expressing Immune Cells. J Immunol. 2017;199:806-815 pubmed publisher
	Starchenko A, Graves Deal R, Yang Y, Li C, Zent R, Singh B, et al. Clustering of integrin Î±5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells. Mol Biol Cell. 2017;28:1288-1300 pubmed publisher
	Michishita M, Ezaki S, Ogihara K, Naya Y, Azakami D, Nakagawa T, et al. Identification of tumor-initiating cells in a canine hepatocellular carcinoma cell line. Res Vet Sci. 2014;96:315-22 pubmed publisher
	Kokkoli E, Ochsenhirt S, Tirrell M. Collective and single-molecule interactions of alpha5beta1 integrins. Langmuir. 2004;20:2397-404 pubmed
	Beauvais D, Rapraeger A. Syndecan-1-mediated cell spreading requires signaling by alphavbeta3 integrins in human breast carcinoma cells. Exp Cell Res. 2003;286:219-32 pubmed
	Malawista S, De Boisfleury Chevance A, Brown E, Boxer L, Law S. Chemotaxis of non-compressed blood polymorphonuclear leukocytes from an adolescent with severe leukocyte adhesion deficiency. Am J Hematol. 2003;73:115-20 pubmed
	Baba T, Udaka K, Terada N, Ueda H, Fujii Y, Ohno S, et al. Actin-rich spherical extrusion induced in okadaic acid-treated K562 cells by crosslinking of membrane microdomains. J Histochem Cytochem. 2003;51:245-52 pubmed
	Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell. 2002;1:445-57 pubmed
	Shen W, Bendall L, Gottlieb D, Bradstock K. The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. Exp Hematol. 2001;29:1439-47 pubmed
	Abe T, Abe Y, Aida Y, Hara Y, Maeda K. Extracellular matrix regulates induction of alkaline phosphatase expression by ascorbic acid in human fibroblasts. J Cell Physiol. 2001;189:144-51 pubmed
	Dillo A, Ochsenhirt S, McCarthy J, Fields G, Tirrell M. Adhesion of alpha5beta1 receptors to biomimetic substrates constructed from peptide amphiphiles. Biomaterials. 2001;22:1493-505 pubmed
	Schulte R, Grassl G, Preger S, Fessele S, Jacobi C, Schaller M, et al. Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J. 2000;14:1471-84 pubmed
	Aguirre Ghiso J, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol. 1999;147:89-104 pubmed
	Stanton K, Frewin M, Gudewicz P. Heterologous desensitization of IL-8-mediated chemotaxis in human neutrophils by a cell-binding fragment of fibronectin. J Leukoc Biol. 1999;65:515-22 pubmed
	Wei Y, Yang X, Liu Q, Wilkins J, Chapman H. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol. 1999;144:1285-94 pubmed
	Brayton J, Qing Z, Hart M, VanGilder J, Fabry Z. Influence of adhesion molecule expression by human brain microvessel endothelium on cancer cell adhesion. J Neuroimmunol. 1998;89:104-12 pubmed
	Arroyo A, Garcia Pardo A, Sanchez Madrid F. A high affinity conformational state on VLA integrin heterodimers induced by an anti-beta 1 chain monoclonal antibody. J Biol Chem. 1993;268:9863-8 pubmed
	Chan B, Elices M, Murphy E, Hemler M. Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. J Biol Chem. 1992;267:8366-70 pubmed

product information

Product Type :

Antibody

Product Name :

ITGB1 Monoclonal Antibody (TS2/16)

Catalog # :

MA2910

Quantity :

200 µg

Price :

US 469.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Human

Clone :

TS2/16

Isotype :

IgG1

Storage :

-20°C

Description :

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta. More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. The distribution pattern in adult tissues for integrin beta types are mutually exclusive. Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.

Immunogen :

Human Beta1 Integrin, the Beta1 chain of the Beta1 integrin heterodimer (CD29)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

4633401G24Rik; AA409975; AA960159; Beta OL; beta oligodendroglia; CD29; CSAT antigen; ENSMUSG00000051907; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; Gm9863; gpIIa; integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta 1A precursor; Integrin beta1; integrin beta-1; integrin beta-1 subunit; integrin beta1D; integrin precursor; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; ITGB1; JG22 antigen; MDF2; MSK12; RGD-receptor; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA

more info or order :

Invitrogen product webpage