Galectin 3 Monoclonal Antibody (A3A12) | Invitrogen MA1-940 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Galectin 3 Monoclonal Antibody (A3A12)

catalog :

MA1-940

quantity :

100 µg

price :

US 412.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A3A12

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1c, 4a	Kasacka I, Piotrowska Z, Niezgoda M, Lewandowska A, Łebkowski W. Ageing-related changes in the levels of β-catenin, CacyBP/SIP, galectin-3 and immunoproteasome subunit LMP7 in the heart of men. PLoS ONE. 2020;15:e0229462 pubmed publisher
immunohistochemistry; mouse; 1:400	Cafiero G, Papale F, Grimaldi A, Rosso F, Barbarisi M, Tortora C, et al. Immunogold labelling in environmental scanning electron microscopy: applicative features for complementary cytological interpretation. J Microsc. 2011;241:83-93 pubmed publisher
immunocytochemistry; rat western blot; rat immunocytochemistry; mouse western blot; mouse	Jeon S, Yoon H, Chang C, Koh H, Jeon S, Park E. Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway. J Immunol. 2010;185:7037-46 pubmed publisher
western blot; rat; 1:1000	Kamal F, Watanabe K, Ma M, Abe Y, Elbarbary R, Kodama M, et al. A novel phenylpyridazinone, T-3999, reduces the progression of autoimmune myocarditis to dilated cardiomyopathy. Heart Vessels. 2011;26:81-90 pubmed publisher
western blot; mouse; 1:1000	Sari F, Watanabe K, Widyantoro B, Thandavarayan R, Harima M, Zhang S, et al. Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice. Cell Physiol Biochem. 2010;26:167-78 pubmed publisher
immunocytochemistry; human	Pais Correia A, Sachse M, Guadagnini S, Robbiati V, Lasserre R, Gessain A, et al. Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses. Nat Med. 2010;16:83-9 pubmed publisher
immunohistochemistry; human	Laiko M, Murtazina R, Malyukova I, Zhu C, Boedeker E, Gutsal O, et al. Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3. Exp Cell Res. 2010;316:657-66 pubmed publisher
western blot; human; 1:2000 western blot; mouse; 1:2000	Farnworth S, Henderson N, Mackinnon A, Atkinson K, Wilkinson T, Dhaliwal K, et al. Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol. 2008;172:395-405 pubmed publisher
	Zhao W, Lu Q, Nguyen M, Su Y, Ziemann M, Wang L, et al. Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway. Br J Pharmacol. 2019;176:2465-2481 pubmed publisher
	Mathew M, Donaldson J. Distinct cargo-specific response landscapes underpin the complex and nuanced role of galectin-glycan interactions in clathrin-independent endocytosis. J Biol Chem. 2018;293:7222-7237 pubmed publisher
	Aragno M, Mastrocola R, Medana C, Restivo F, Catalano M, Pons N, et al. Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment. Endocrinology. 2005;146:5561-7 pubmed
	Kikuchi Y, Kobayashi S, Hemmi N, Ikee R, Hyodo N, Saigusa T, et al. Galectin-3-positive cell infiltration in human diabetic nephropathy. Nephrol Dial Transplant. 2004;19:602-7 pubmed
	Martins L, Matsuo S, Ebina K, Kulcsar M, Friguglietti C, Kimura E. Galectin-3 messenger ribonucleic acid and protein are expressed in benign thyroid tumors. J Clin Endocrinol Metab. 2002;87:4806-10 pubmed
	Yang R, Hsu D, Liu F. Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci U S A. 1996;93:6737-42 pubmed
	Liu F, Hsu D, Zuberi R, Hill P, Shenhav A, Kuwabara I, et al. Modulation of functional properties of galectin-3 by monoclonal antibodies binding to the non-lectin domains. Biochemistry. 1996;35:6073-9 pubmed

image

image 1 :

Immunolocalization of galectin-3 in rat olfactory bulb using MA1-940.

product information

Product Type :

Antibody

Product Name :

Galectin 3 Monoclonal Antibody (A3A12)

Catalog # :

MA1-940

Quantity :

100 µg

Price :

US 412.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Frozen): 6 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

A3A12

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Immunogen :

Full length recombinant human galectin-3.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Frozen): 6 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1,000

Aliases :

35 kDa lectin; advanced glycation end-product receptor 3; AGE-R3; beta-galactosides-binding lectin; carbohydrate-binding protein 35; CBP 35; CBP30; CBP-30; CBP35; epsilon BP; gal3; gal-3; galactose-specific lectin 3; Galactoside-binding protein; GALBP; galectin 3; Galectin3; galectin-3; GALIG; GBP; IgE binding protein; igE-binding protein; L-29; L31; L-31; L-34; L-34 galactoside-binding lectin; Laminin-binding protein; lectin galactoside-binding soluble 3; lectin galactoside-binding soluble 3 protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside binding soluble 3; lectin, galactoside-binding, soluble, 3; lectin, galactoside-binding, soluble, 3 (galectin 3); LGALS2; Lgals3; MAC2; Mac-2; Mac-2 antigen

more info or order :

Invitrogen product webpage