CFTR Monoclonal Antibody (CF3) | Invitrogen MA1-935 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CFTR Monoclonal Antibody (CF3)

catalog :

MA1-935

quantity :

100 µL

price :

US 412.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CF3

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human	Bravo D, Blondel C, Hoare A, Leyton L, Valvano M, Contreras I. Type IV(B) pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner. Microb Pathog. 2011;51:373-7 pubmed publisher
immunohistochemistry; rat; 1:1000 western blot; human	Boom A, Lybaert P, Pollet J, Jacobs P, Jijakli H, Golstein P, et al. Expression and localization of cystic fibrosis transmembrane conductance regulator in the rat endocrine pancreas. Endocrine. 2007;32:197-205 pubmed
immunohistochemistry; human; 1 ug/ml	Rottner M, Kunzelmann C, Mergey M, Freyssinet J, Martinez M. Exaggerated apoptosis and NF-kappaB activation in pancreatic and tracheal cystic fibrosis cells. FASEB J. 2007;21:2939-48 pubmed
immunocytochemistry; rat; 1:50	Kulka M, Dery R, Nahirney D, Duszyk M, Befus A. Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J Pharmacol Exp Ther. 2005;315:563-70 pubmed
	Di Fulvio M, Bogdani M, Velasco M, McMillen T, Ridaura C, Kelly L, et al. Heterogeneous expression of CFTR in insulin-secreting β-cells of the normal human islet. PLoS ONE. 2020;15:e0242749 pubmed publisher
	Mendes F, Farinha C, Roxo Rosa M, Fanen P, Edelman A, Dormer R, et al. Antibodies for CFTR studies. J Cyst Fibros. 2004;3 Suppl 2:69-72 pubmed
	Dalby Payne J, O Loughlin E, Gunning P. Polarization of specific tropomyosin isoforms in gastrointestinal epithelial cells and their impact on CFTR at the apical surface. Mol Biol Cell. 2003;14:4365-75 pubmed
	Kulka M, Gilchrist M, Duszyk M, Befus A. Expression and functional characterization of CFTR in mast cells. J Leukoc Biol. 2002;71:54-64 pubmed
	Pier G, Grout M, Zaidi T, Meluleni G, Mueschenborn S, Banting G, et al. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature. 1998;393:79-82 pubmed
	Walker J, Watson J, Holmes C, Edelman A, Banting G. Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci. 1995;108 ( Pt 6):2433-44 pubmed

product information

Product Type :

Antibody

Product Name :

CFTR Monoclonal Antibody (CF3)

Catalog # :

MA1-935

Quantity :

100 µL

Price :

US 412.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1/100, Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Species :

Human, Mouse

Clone :

CF3

Isotype :

IgM

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.

Immunogen :

Synthetic Peptide: G(103) R I I A S Y D P D N K E E R(117)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1/100, Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Aliases :

ABC35; Abcc7; ATP Binding Cassette Superfamily C Member 7 (ABCC7); ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; AW495489; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7; dJ760C5.1; MRP7; RGD1561193; tcag7.78; TNR CFTR; TNR-CFTR

more info or order :

Invitrogen product webpage