Adenovirus Type 5 E1A Monoclonal Antibody (0.N.8) | Invitrogen MA1-91861 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Adenovirus Type 5 E1A Monoclonal Antibody (0.N.8)

catalog :

MA1-91861

quantity :

250µL

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

0.N.8

reactivity :

Human adenovirus C

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

Adenovirus Type 5 E1A Monoclonal Antibody (0.N.8)

Catalog # :

MA1-91861

Quantity :

250µL

Price :

US 375.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Virus

Applications :

Immunocytochemistry: Assay-dependent, Immunofluorescence: 0.2-0.4 µg/ml, Immunohistochemistry (Frozen): 2-4 µg/ml, Immunoprecipitation: 2 µg/mg of protein lysate, Western Blot: 0.5-1 µg/ml

Species :

Virus

Clone :

0.N.8

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). 49 human adenovirus serotypes have been discovered and divided into six subgroups, A to E, based on observation. They are an important cause of respiratory illness, conjunctivitis, gastroenteritis, and have more recently been recognized as a potential cause of sexually transmitted diseases. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterized by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated, causing disease. Adenovirus vectors, particularly those based on Ad5, have shown great promise for the development of gene therapy protocols and have been used for clinical purpose. The early region (E1A) of the adenovirus genome plays a central role in cellular transformation and regulation of gene expression. The E1A region encodes a series of related proteins (35-46kDa) with multifuctional capabilities and form a specific complex with the retinoblastoma tumor suppressor gene product (Rb protein). The E1A and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region. Several conserved regions of E1A are similar to portions of other viral oncoproteins like the HPV-16 and HPV-18 E7 and SV40 large T antigen.

Immunogen :

Tissue / cell preparation adenovirus.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunofluorescence: 0.2-0.4 µg/ml, Immunohistochemistry (Frozen): 2-4 µg/ml, Immunoprecipitation: 2 µg/mg of protein lysate, Western Blot: 0.5-1 µg/ml

Aliases :

HADV; AdV; Adeno Virus; HADV-5; AdV-5; Adeno Virus 5