NOTCH1 Monoclonal Antibody (A6) | Invitrogen MA1-91405 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NOTCH1 Monoclonal Antibody (A6)

catalog :

MA1-91405

quantity :

500 µL

price :

US 399.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:500; fig 1	Mathan J, Ismail S, McGhee J, McGhee C, Sherwin T. Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface. Stem Cell Res Ther. 2016;7:81 pubmed publisher
immunohistochemistry; human	Krausch M, Kroepil F, Lehwald N, Lachenmayer A, Schott M, Anlauf M, et al. Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors. Endocrine. 2013;44:182-6 pubmed publisher
blocking or activating experiments; human; 10 ug/ml	Del Papa B, Sportoletti P, Cecchini D, Rosati E, Balucani C, Baldoni S, et al. Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction. Eur J Immunol. 2013;43:182-7 pubmed publisher
flow cytometry; mouse	Perumalsamy L, Marcel N, Kulkarni S, Radtke F, Sarin A. Distinct spatial and molecular features of notch pathway assembly in regulatory T cells. Sci Signal. 2012;5:ra53 pubmed publisher
blocking or activating experiments; human; 20 ug/ml	Pei J, Tang Z, Zang G, Yu Y. Blockage of Notch1 signaling modulates the T-helper (Th)1/Th2 cell balance in chronic hepatitis B patients. Hepatol Res. 2010;40:799-805 pubmed publisher
flow cytometry; human; 1:100	Puget S, Grill J, Valent A, Bieche I, Dantas Barbosa C, Kauffmann A, et al. Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas. J Clin Oncol. 2009;27:1884-92 pubmed publisher
immunohistochemistry; human; 10-20 ug/ml	Kose O, Lalli A, Kutulola A, Odell E, Waseem A. Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. J Oral Sci. 2007;49:133-9 pubmed
immunocytochemistry; human ELISA; human	Luty W, Rodeberg D, Parness J, Vyas Y. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J Immunol. 2007;179:819-29 pubmed
immunohistochemistry; human; 1:100	Su Y, Buchler P, Gazdhar A, Giese N, Reber H, Hines O, et al. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J Gastrointest Surg. 2006;10:1230-41; discussion 1242 pubmed
western blot; mouse; 2 ug/ml	Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A. Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol. 2006;177:5041-50 pubmed
immunohistochemistry; human	Blaukovitsch M, Halbwedl I, Kothmaier H, Gogg Kammerer M, Popper H. Sarcomatoid carcinomas of the lung--are these histogenetically heterogeneous tumors?. Virchows Arch. 2006;449:455-61 pubmed
immunohistochemistry; human; 1:100	Buchler P, Gazdhar A, Schubert M, Giese N, Reber H, Hines O, et al. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005;242:791-800, discussion 800-1 pubmed
immunohistochemistry; human; 1:250	Morsczeck C, Gotz W, Schierholz J, Zeilhofer F, Kuhn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155-65 pubmed
immunohistochemistry; human; 1:200 western blot; human; 1:100	Purow B, Haque R, Noel M, Su Q, Burdick M, Lee J, et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 2005;65:2353-63 pubmed
blocking or activating experiments; mouse	Sakamoto K, Chao W, Katsube K, Yamaguchi A. Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res. 2005;302:281-91 pubmed
	Cui X, Hu Q, Tekaya M, Shimoda Y, Ang B, Nie D, et al. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J Biol Chem. 2004;279:25858-65 pubmed

product information

Product Type :

Antibody

Product Name :

NOTCH1 Monoclonal Antibody (A6)

Catalog # :

MA1-91405

Quantity :

500 µL

Price :

US 399.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 1:50

Species :

Human, Mouse

Clone :

Isotype :

IgG2b

Storage :

4° C, do not freeze

Description :

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Immunogen :

Recombinant protein encoding the ligand binding region of human Notch 1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 1:50

Aliases :

9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; Notch1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1

more info or order :

Invitrogen product webpage