CD45RB Monoclonal Antibody (MEM55) | Invitrogen MA1-90840 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45RB Monoclonal Antibody (MEM55)

catalog :

MA1-90840

quantity :

200 µg

price :

US 484

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MEM55

reactivity :

human, rhesus macaque

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 4	Hatachi S, Iwai Y, Kawano S, Morinobu S, Kobayashi M, Koshiba M, et al. CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid. J Rheumatol. 2003;30:1410-9 pubmed
	Farmer J, Allard Chamard H, Sun N, Ahmad M, Bertocchi A, Mahajan V, et al. Induction of metabolic quiescence defines the transitional to follicular B cell switch. Sci Signal. 2019;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45RB Monoclonal Antibody (MEM55)

Catalog # :

MA1-90840

Quantity :

200 µg

Price :

US 484

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Non-human primate, Rhesus Monkey

Applications :

Flow Cytometry: 1:50-1:100, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Immunoprecipitation: Assay-dependent

Species :

Human, Non-human primate, Rhesus Monkey

Clone :

MEM55

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.

Immunogen :

Purified MEM55

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:100, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Immunoprecipitation: Assay-dependent

Aliases :

B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; Leukocyte common antigen; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen

more info or order :

Invitrogen product webpage