Tn Antigen Monoclonal Antibody (Tn 218) | Invitrogen MA1-90544 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tn Antigen Monoclonal Antibody (Tn 218)

catalog :

MA1-90544

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Tn 218

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Tn Antigen Monoclonal Antibody (Tn 218)

Catalog # :

MA1-90544

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: Assay-dependent

Species :

Human

Clone :

Tn 218

Isotype :

IgM

Storage :

4 C, do not freeze

Description :

Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approximately 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells. Fundamental, chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primamry breast carcinoma demonstrate its highly significant correlation with clinical pathological tumor stages, and hence its value as a reliable prognisticator.

Immunogen :

Asialo ovine submaxillary mucin (AOSM).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: Assay-dependent

Aliases :

Thomsen-Friedenreich antigen