SRC1 Monoclonal Antibody (1135/H4) | Invitrogen MA1-840 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SRC1 Monoclonal Antibody (1135/H4)

catalog :

MA1-840

quantity :

100 µL

price :

US 420.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1135/H4

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; mouse; fig 3c	Kumar S, Cunningham T, Duester G. Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Dev Biol. 2016;418:204-215 pubmed publisher
immunoprecipitation; human western blot; human	Meneses Morales I, Tecalco Cruz A, Barrios Garcia T, Gómez Romero V, Trujillo Gonzalez I, Reyes Carmona S, et al. SIP1/NHERF2 enhances estrogen receptor alpha transactivation in breast cancer cells. Nucleic Acids Res. 2014;42:6885-900 pubmed publisher
immunoprecipitation; human	Merenbakh Lamin K, Ben Baruch N, Yeheskel A, Dvir A, Soussan Gutman L, Jeselsohn R, et al. D538G mutation in estrogen receptor-?: A novel mechanism for acquired endocrine resistance in breast cancer. Cancer Res. 2013;73:6856-64 pubmed publisher
immunohistochemistry; human	Kumagami A, Ito A, Yoshida Komiya H, Fujimori K, Sato A. Expression patterns of the steroid receptor coactivator family in human ovarian endometriosis. J Obstet Gynaecol Res. 2011;37:1269-76 pubmed publisher
western blot; human; 1:2000	Zhang Z, Kovalenko P, Cui M, Desmet M, Clinton S, Fleet J. Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells. J Cell Physiol. 2010;224:433-42 pubmed publisher
	Li G, Heaton J, Gelehrter T. Role of steroid receptor coactivators in glucocorticoid and transforming growth factor beta regulation of plasminogen activator inhibitor gene expression. Mol Endocrinol. 2006;20:1025-34 pubmed
	Agoulnik I, Vaid A, Bingman W, Erdeme H, Frolov A, Smith C, et al. Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res. 2005;65:7959-67 pubmed
	Ruas J, Poellinger L, Pereira T. Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci. 2005;118:301-11 pubmed
	Zhang C, Dowd D, Staal A, Gu C, Lian J, Van Wijnen A, et al. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 2003;278:35325-36 pubmed
	Li Q, Su A, Chen J, Lefebvre Y, Haché R. Attenuation of glucocorticoid signaling through targeted degradation of p300 via the 26S proteasome pathway. Mol Endocrinol. 2002;16:2819-27 pubmed
	Gregory C, Wilson E, Apparao K, Lininger R, Meyer W, Kowalik A, et al. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. J Clin Endocrinol Metab. 2002;87:2960-6 pubmed
	Sharma D, Fondell J. Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. Proc Natl Acad Sci U S A. 2002;99:7934-9 pubmed
	Yi M, Tong G, Murry B, Mendelson C. Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1). J Biol Chem. 2002;277:2997-3005 pubmed
	Sharma D, Fondell J. Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells. Mol Endocrinol. 2000;14:2001-9 pubmed
	Tikkanen M, Carter D, Harris A, Le H, Azorsa D, Meltzer P, et al. Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells. Proc Natl Acad Sci U S A. 2000;97:12536-40 pubmed
	Klein E, Wang J, Khalifa B, Gavigan S, Chandraratna R. Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions. J Biol Chem. 2000;275:19401-8 pubmed
	Lanz R, McKenna N, Onate S, Albrecht U, Wong J, Tsai S, et al. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999;97:17-27 pubmed
	Xu J, Qiu Y, DeMayo F, Tsai S, Tsai M, O Malley B. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998;279:1922-5 pubmed
	Spencer T, Jenster G, Burcin M, Allis C, Zhou J, Mizzen C, et al. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature. 1997;389:194-8 pubmed

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product information

Product Type :

Antibody

Product Name :

SRC1 Monoclonal Antibody (1135/H4)

Catalog # :

MA1-840

Quantity :

100 µL

Price :

US 420.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate

Applications :

ChIP Assay: 5 µL / 10^6 cells, Flow Cytometry: 1 µg / 10^6 cells, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:5,000

Species :

Human, Mouse, Non-human primate

Clone :

1135/H4

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Clone 1135 recognizes SRC-1, steroid-receptor coactivator-1. SRC-1 is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain.

Immunogen :

Synthetic peptide corresponding to residues 477-947 of human SRC-1.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 5 µL / 10^6 cells, Flow Cytometry: 1 µg / 10^6 cells, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:5,000

Aliases :

ASV; bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; c-SRC; F-SRC-1; Hin-2 protein; KAT13A; mNRC-1; NCOA1; NCoA-1; Nuclear receptor coactivator 1; nuclear receptor coactivator protein 1; p60-Src; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; Src1; SRC-1; SRC-1 (-Q); SRC-a/NCoA-1; Steroid receptor coactivator 1; steroid receptor coactivator-1

more info or order :

Invitrogen product webpage