Apolipoprotein J Monoclonal Antibody (3R3/2) | Invitrogen MA1-83879 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Apolipoprotein J Monoclonal Antibody (3R3/2)

catalog :

MA1-83879

quantity :

100 ug

price :

US 676.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3R3/2

The same clone is also sold as:

Bio-Rad: MCA2612
OriGene: AM01332PU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 1

Reference
Singleton D, Wu T, Castle J. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. J Cell Sci. 1997;110 ( Pt 17):2099-107 pubmed

product information

Product Type :

Antibody

Product Name :

Apolipoprotein J Monoclonal Antibody (3R3/2)

Catalog # :

MA1-83879

Quantity :

100 ug

Price :

US 676.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1 ug/mL

Species :

Human

Clone :

3R3/2

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Immunogen :

Glomerular basement membrane from a post-mortem kidney.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1 ug/mL

Aliases :

AAG4; Aging associated protein 4; Aging-associated gene 4 protein; aging-associated protein 4; AI893575; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J a; Apo J ß; Apo Ja; Apo Jb; ApoJ; Apo-J; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ a; ApoJ ß; ApoJa; ApoJalpha; ApoJb; ApoJbeta; Apolipoprotein J; CLI; Clu; CLU1; CLU2; clusterin; Clusterin alpha / beta chain; Clusterin alpha chain; Clusterin beta chain; Clustrin; Complement associated protein SP40; complement cytolysis inhibitor; Complement cytolysis inhibitor a chain; Complement cytolysis inhibitor b chain; complement lysis inhibitor; complement-associated protein SP-40,40; D14Ucla3; DAG; Dimeric acid glycoprotein; GP80; HGNC:2095; ku70-binding protein 1; Ku70-binding protein 1 (KUB1); KUB1; MGC24903; Msgp-2; NA1/NA2; RATTRPM2B; SGP2; Sgp-2; SP40; SP-40; Sugp-2; sulfated glycoprotein 2; Sulfated glycoprotein 2 (SGP2); testosterone repressed prostate message; testosterone repressed prostate message 2; Testosterone repressed prostate message 2 (TPRM2B); testosterone repressed prostate message-2; testosterone-repressed prostate message; testosterone-repressed prostate message 2; testostrone-repressed prostate message 2; Trpm2; TRPM-2; TRPM2B; Trpmb