PrP Monoclonal Antibody (2G11) | Invitrogen MA1-82828 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PrP Monoclonal Antibody (2G11)

catalog :

MA1-82828

quantity :

250 ug

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G11

The same clone is also sold as:

OriGene: AM01216PU-N
Bio-Rad: MCA2460

reactivity :

domestic sheep

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 4

Reference
Mettler S, Ghayouri S, Christensen G, Forte J. Modulatory role of phosphoinositide 3-kinase in gastric acid secretion. Am J Physiol Gastrointest Liver Physiol. 2007;293:G532-43 pubmed
Sawaguchi A, McDonald K, Forte J. High-pressure freezing of isolated gastric glands provides new insight into the fine structure and subcellular localization of H+/K+-ATPase in gastric parietal cells. J Histochem Cytochem. 2004;52:77-86 pubmed
Ammar D, Nguyen P, Forte J. Functionally distinct pools of actin in secretory cells. Am J Physiol Cell Physiol. 2001;281:C407-17 pubmed
Duman J, Tyagarajan K, Kolsi M, Moore H, Forte J. Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. Am J Physiol. 1999;277:C361-72 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PrP Monoclonal Antibody (2G11)

Catalog # :

MA1-82828

Quantity :

250 ug

Price :

US 484.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Ovine

Applications :

Immunohistochemistry (Paraffin): Assay-dependent

Species :

Ovine

Clone :

2G11

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.

Immunogen :

Synthetic peptide corresponding to 146-R(154)R(171)-182 of ovine PrP

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): Assay-dependent

Aliases :

AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP ; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE