CD18 Monoclonal Antibody (CA1.4E9) | Invitrogen MA1-82363 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD18 Monoclonal Antibody (CA1.4E9)

catalog :

MA1-82363

quantity :

100µg

price :

US 338

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CA1.4E9

reactivity :

human, dogs, bovine, swine, cat, domestic horse

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

CD18 Monoclonal Antibody (CA1.4E9)

Catalog # :

MA1-82363

Quantity :

100µg

Price :

US 338

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Canine, Equine, Feline, Human, Mustelid, Porcine

Applications :

Flow Cytometry: 1:25 - 1:200, Immunofluorescence: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunoprecipitation: Assay Dependent

Species :

Bovine, Canine, Equine, Feline, Human, Mustelid, Porcine

Clone :

CA1.4E9

Isotype :

IgG1

Storage :

4°C or -20°C if preferred

Description :

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.

Immunogen :

Proprietary Immunogen.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:25 - 1:200, Immunofluorescence: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunoprecipitation: Assay Dependent

Aliases :

CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7