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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (YTS191.1)
catalog :
MA1-82247
quantity :
100 ug
price :
US 241.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
YTS191.1
reactivity :
mouse
application :
immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 13
| Published Application/Species/Sample/Dilution | Reference |
|---|---|
| Mendes da Cruz D, De Meis J, Cotta de Almeida V, Savino W. Experimental Trypanosoma cruzi infection alters the shaping of the central and peripheral T-cell repertoire. Microbes Infect. 2003;5:825-32 pubmed
|
| Shinkai K, Mohrs M, Locksley R. Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002;420:825-9 pubmed
|
| Chen Y, Ma Y, Chen Y. Roles of cytotoxic T-lymphocyte-associated antigen-4 in the inductive phase of oral tolerance. Immunology. 2002;105:171-80 pubmed
|
| Penttilä J, Anttila M, Varkila K, Puolakkainen M, Sarvas M, Makela P, et al. Depletion of CD8+ cells abolishes memory in acquired immunity against Chlamydia pneumoniae in BALB/c mice. Immunology. 1999;97:490-6 pubmed
|
| Rouleau M, Cottrez F, Bigler M, Antonenko S, Carballido J, Zlotnik A, et al. IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients. J Immunol. 1999;163:1420-7 pubmed
|
| Inaba M, Kurasawa K, Mamura M, Kumano K, Saito Y, Iwamoto I. Primed T cells are more resistant to Fas-mediated activation-induced cell death than naive T cells. J Immunol. 1999;163:1315-20 pubmed
|
| Timm J, Thoman M. Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population. J Immunol. 1999;162:711-7 pubmed
|
| Bix M, Wang Z, Thiel B, Schork N, Locksley R. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med. 1998;188:2289-99 pubmed
|
| Liu L, Rich B, Inobe J, Chen W, Weiner H. Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4. Int Immunol. 1998;10:1017-26 pubmed
|
| Moore T, von Freeden Jeffry U, Murray R, Zlotnik A. Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J Immunol. 1996;157:2366-73 pubmed
|
| Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubata T, Yagita H, et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol. 1996;8:765-72 pubmed
|
| Wadsworth S, Chang A, Hong M, Halvorson M, Otto S, Coligan J. Expression of a novel integrin beta 1 chain epitope and anti-beta 1 antibody-mediated enhancement of fibronectin binding are dependent on the stage of T cell differentiation. J Immunol. 1995;154:2125-33 pubmed
|
| Schuyler M, Gott K, Shopp G, Crooks L. CD3+ and CD4+ cells adoptively transfer experimental hypersensitivity pneumonitis. Am Rev Respir Dis. 1992;146:1582-8 pubmed
|
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (YTS191.1)
Catalog # :
MA1-82247
Quantity :
100 ug
Price :
US 241.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1:50-1:200, Immunohistochemistry (Frozen): Assay-dependent
Species :
Mouse
Clone :
YTS191.1
Isotype :
IgG2b
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Immunogen :
Proprietary Immunogen.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:50-1:200, Immunohistochemistry (Frozen): Assay-dependent
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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