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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PPAR alpha Monoclonal Antibody (3B6/PPAR)
catalog :
MA1-822
quantity :
100 ug
price :
US 471.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3B6/PPAR
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
Invitrogen product webpage
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2c
Lin Y, Tai S, Chen J, Chou C, Fu S, Chen Y. Ameliorative effects of pepsin-digested chicken liver hydrolysates on development of alcoholic fatty livers in mice. Food Funct. 2017;8:1763-1774 pubmed publisher
  • western blot; rat
Conti R, Mannucci E, Pessotto P, Tassoni E, Carminati P, Giannessi F, et al. Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis. Diabetes. 2011;60:644-51 pubmed publisher
  • immunohistochemistry; rat; 1:200
  • western blot; rat; 1:200
Crespillo A, Suarez J, Bermudez Silva F, Rivera P, Vida M, Alonso M, et al. Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade. Biochem J. 2011;433:175-85 pubmed publisher
  • immunoprecipitation; mouse
  • western blot; mouse; 5 ug/ml
Alwayn I, Andersson C, Lee S, Arsenault D, Bistrian B, Gura K, et al. Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am J Physiol Gastrointest Liver Physiol. 2006;291:G1011-9 pubmed
Oswal N, Thangavel H, Lizardo K, Dhanyalayam D, Sidrat T, Salgame P, et al. Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection. Life (Basel). 2023;13: pubmed publisher
Górowska Wójtowicz E, Duliban M, Kotula Balak M, Bilinska B. Modulatory Effects of Estradiol and Its Mixtures with Ligands of GPER and PPAR on MAPK and PI3K/Akt Signaling Pathways and Tumorigenic Factors in Mouse Testis Explants and Mouse Tumor Leydig Cells. Biomedicines. 2022;10: pubmed publisher
Suh J, Kim K, Conner M, Moore D, Preidis G. Hepatic PPARα Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice. Front Nutr. 2022;9:831879 pubmed publisher
Oswal N, Lizardo K, Dhanyalayam D, Ayyappan J, Thangavel H, Heysell S, et al. Host Metabolic Changes during Mycobacterium Tuberculosis Infection Cause Insulin Resistance in Adult Mice. J Clin Med. 2022;11: pubmed publisher
Paciello F, Pisani A, Rolesi R, Escarrat V, Galli J, Paludetti G, et al. Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation. Antioxidants (Basel). 2021;10: pubmed publisher
Jiang H, Zhou Y, Zhou P, Zhang T, Hu J, Bai X. Protective Effects of Bariatric Surgery on Kidney Functions by Inhibiting Oxidative Stress Responses Through Activating PPARα in Rats With Diabetes. Front Physiol. 2021;12:662666 pubmed publisher
Majeed Y, Halabi N, Madani A, Engelke R, Bhagwat A, Abdesselem H, et al. SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways. Sci Rep. 2021;11:8177 pubmed publisher
Lizardo K, Ayyappan J, Oswal N, Weiss L, Scherer P, Nagajyothi J. Fat tissue regulates the pathogenesis and severity of cardiomyopathy in murine chagas disease. PLoS Negl Trop Dis. 2021;15:e0008964 pubmed publisher
Preidis G, Soni K, Suh J, Halder T, Kim K, Choi J, et al. Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatol Commun. 2020;4:1835-1850 pubmed publisher
Tam V, Suen R, Treuting P, Armando A, Lucarelli R, Gorrochotegui Escalante N, et al. PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection. Proc Natl Acad Sci U S A. 2020;117:15789-15798 pubmed publisher
Kotula Balak M, Gorowska Wojtowicz E, Milon A, Pawlicki P, Tworzydlo W, Płachno B, et al. Towards understanding leydigioma: do G protein-coupled estrogen receptor and peroxisome proliferator-activated receptor regulate lipid metabolism and steroidogenesis in Leydig cell tumors?. Protoplasma. 2020;257:1149-1163 pubmed publisher
Ayyappan J, Lizardo K, Wang S, Yurkow E, Nagajyothi J. Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy. J Am Heart Assoc. 2020;9:e014255 pubmed publisher
Ayyappan J, Ganapathi U, Lizardo K, Vinnard C, Subbian S, Perlin D, et al. Adipose Tissue Regulates Pulmonary Pathology during TB Infection. MBio. 2019;10: pubmed publisher
Gorowska Wojtowicz E, Dutka P, Kudrycka M, Pawlicki P, Milon A, Plachno B, et al. Regulation of steroidogenic function of mouse Leydig cells: G-coupled membrane estrogen receptor and peroxisome proliferator-activated receptor partnership. J Physiol Pharmacol. 2018;69: pubmed publisher
Liu Y, Heymann R, Moatamed F, Schultz J, Sobel D, Brent G. A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation. Endocrinology. 2007;148:1206-17 pubmed
Mouthiers A, Baillet A, Delomenie C, Porquet D, Mejdoubi Charef N. Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression. Mol Endocrinol. 2005;19:1135-46 pubmed
Lindgren E, Nielsen R, Petrovic N, Jacobsson A, Mandrup S, Cannon B, et al. Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels. Biochem J. 2004;382:597-606 pubmed
Karbowska J, Kochan Z, Smolenski R. Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart. Cell Mol Biol Lett. 2003;8:49-53 pubmed
Sumanasekera W, Tien E, Turpey R, Vanden Heuvel J, Perdew G. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem. 2003;278:4467-73 pubmed
Watanabe A, Miyamoto T, Katoh N, Takahashi Y. Effect of stages of lactation on the concentration of a 90-kilodalton heat shock protein in bovine mammary tissue. J Dairy Sci. 1997;80:2372-9 pubmed
product information
Product Type :
Antibody
Product Name :
PPAR alpha Monoclonal Antibody (3B6/PPAR)
Catalog # :
MA1-822
Quantity :
100 ug
Price :
US 471.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
ChIP Assay: Assay-dependent, Flow Cytometry: 1 ug / 10^6 cells, Gel Shift: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 2-5 ug/mL
Species :
Human, Mouse, Rat
Clone :
3B6/PPAR
Isotype :
IgG2b
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.
Immunogen :
Purified recombinant PPAR alpha protein.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: Assay-dependent, Flow Cytometry: 1 ug / 10^6 cells, Gel Shift: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 2-5 ug/mL
Aliases :
4933429D07Rik; AW742785; hPPAR; I79_022392; MGC2237; MGC2452; Nr1c1; nuclear hormone receptor; nuclear receptor; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor alpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferative activated receptor, alpha isoform 1; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPAR ALPHA; Ppara; PPARALPHA; PPAR-alpha; proliferator-activated receptor alpha; transcription factor belonging to the nuclear receptor superfamily
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA