ITGB1 Monoclonal Antibody (4B7R), PE | Invitrogen MA1-82003 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ITGB1 Monoclonal Antibody (4B7R), PE

catalog :

MA1-82003

quantity :

100 Tests

price :

US 442.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

4B7R

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1 ug/ml	Rossier O, Octeau V, Sibarita J, Leduc C, Tessier B, Nair D, et al. Integrins ?1 and ?3 exhibit distinct dynamic nanoscale organizations inside focal adhesions. Nat Cell Biol. 2012;14:1057-67 pubmed publisher
immunohistochemistry; human	Qi H, Zheng X, Yuan X, Pflugfelder S, Li D. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010;225:180-5 pubmed publisher
flow cytometry; human immunocytochemistry; human	Millon Fremillon A, Bouvard D, Grichine A, Manet Dupé S, Block M, Albiges Rizo C. Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity. J Cell Biol. 2008;180:427-41 pubmed publisher
flow cytometry; human	Li H, Zhou J, Miki J, Furusato B, Gu Y, Srivastava S, et al. Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells. Exp Cell Res. 2008;314:92-102 pubmed
flow cytometry; mouse	Miki J, Furusato B, Li H, Gu Y, Takahashi H, Egawa S, et al. Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res. 2007;67:3153-61 pubmed
immunocytochemistry; human; 1:50	Poincloux R, Vincent C, Labrousse A, Castandet J, Rigo M, Cougoule C, et al. Re-arrangements of podosome structures are observed when Hck is activated in myeloid cells. Eur J Cell Biol. 2006;85:327-32 pubmed
immunocytochemistry; human; 1:200	Chen Z, Evans W, Pflugfelder S, Li D. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells. 2006;24:1265-73 pubmed
immunocytochemistry; human; 1:200 immunohistochemistry; human; 1:200	Li D, Chen Z, Song X, de Paiva C, Kim H, Pflugfelder S. Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005;80:581-90 pubmed
	Chen Z, de Paiva C, Luo L, Kretzer F, Pflugfelder S, Li D. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004;22:355-66 pubmed
	Jolicoeur F, Gaboury L, Oligny L. Basal cells of second trimester fetal breasts: immunohistochemical study of myoepithelial precursors. Pediatr Dev Pathol. 2003;6:398-413 pubmed

product information

Product Type :

Antibody

Product Name :

ITGB1 Monoclonal Antibody (4B7R), PE

Catalog # :

MA1-82003

Quantity :

100 Tests

Price :

US 442.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Neat-1:2

Species :

Human

Clone :

4B7R

Isotype :

IgG1

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta. More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. The distribution pattern in adult tissues for integrin beta types are mutually exclusive. Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.

Immunogen :

Ocular melanoma cell line V+B2.

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: Neat-1:2

Aliases :

4633401G24Rik; AA409975; AA960159; Beta OL; beta oligodendroglia; CD29; CSAT antigen; ENSMUSG00000051907; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; Gm9863; gpIIa; integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta 1A precursor; Integrin beta1; integrin beta-1; integrin beta-1 subunit; integrin beta1D; integrin precursor; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; ITGB1; JG22 antigen; MDF2; MSK12; RGD-receptor; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA

more info or order :

Invitrogen product webpage