Glucocorticoid Receptor Monoclonal Antibody (5E4), FITC | Invitrogen MA1-81793 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Glucocorticoid Receptor Monoclonal Antibody (5E4), FITC

catalog :

MA1-81793

quantity :

100 ug

price :

US 842.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

5.00E+04

reactivity :

human, mouse

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:100	Shibata A, Troster E, Wong H. Glucocorticoid Receptor Expression in Peripheral WBCs of Critically Ill Children. Pediatr Crit Care Med. 2015;16:e132-40 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Glucocorticoid Receptor Monoclonal Antibody (5E4), FITC

Catalog # :

MA1-81793

Quantity :

100 ug

Price :

US 842.00

Clonality :

Monoclonal

Purity :

Ion-exchange chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Neat-1:10, Immunocytochemistry: 5 ug/mL

Species :

Human

Clone :

5.00E+04

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles. Store in the dark.

Description :

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity

Immunogen :

26 amino acid peptide corresponding to residues 150-176 on human GCR linked thyroglobulin.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Neat-1:10, Immunocytochemistry: 5 ug/mL

Aliases :

cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038

more info or order :

Invitrogen product webpage