C5AR1 Monoclonal Antibody (10/92) | Invitrogen MA1-81761 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

C5AR1 Monoclonal Antibody (10/92)

catalog :

MA1-81761

quantity :

100 ug

price :

US 229.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

Oct-92

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 4

Reference
McCullough L, Roy O Reilly M, Lai Y, Patrizz A, Xu Y, Lee J, et al. Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice. J Clin Invest. 2021;131: pubmed publisher
Mödinger Y, Rapp A, Pázmándi J, Vikman A, Holzmann K, Haffner Luntzer M, et al. C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10. J Cell Mol Med. 2018;22:6002-6014 pubmed publisher
Natarajan N, Abbas Y, Bryant D, González Rosa J, Sharpe M, Uygur A, et al. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018;137:2152-2165 pubmed publisher
Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, et al. Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. PLoS ONE. 2017;12:e0179512 pubmed publisher

product information

Product Type :

Antibody

Product Name :

C5AR1 Monoclonal Antibody (10/92)

Catalog # :

MA1-81761

Quantity :

100 ug

Price :

US 229.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1:50-1:100, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent

Species :

Mouse

Clone :

Oct-92

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.

Immunogen :

RBL-2H3 transfected cells expressing murine C5aR.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:100, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent

Aliases :

anaphylatoxin C5a receptor; C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5AR; C5a-R; C5AR1; C5r1; Cd88; CD88 antigen; complement C5a receptor; complement C5a receptor 1; complement component 5 receptor 1; complement component 5, receptor 1; complement component 5a receptor 1; D7Msu1