CD45 Monoclonal Antibody (1.11.32), PE | Invitrogen MA1-81458 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45 Monoclonal Antibody (1.11.32), PE

catalog :

MA1-81458

quantity :

100 Tests

price :

US 718.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

1.11.32

reactivity :

domestic goat, human, bovine, pigs , domestic sheep

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
flow cytometry; pigs ; loading ...	Beigi F, Patel M, Morales Garza M, Winebrenner C, Gobin A, Chau E, et al. Optimized method for isolating highly purified and functional porcine aortic endothelial and smooth muscle cells. J Cell Physiol. 2017;232:3139-3145 pubmed publisher
flow cytometry; bovine	Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
flow cytometry; bovine	Turner M, Cronin J, Healey G, Sheldon I. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Endocrinology. 2014;155:1453-65 pubmed publisher
flow cytometry; human	Chan C, Hilton A, Foster G, Hawkins K, Badiei N, Thornton C. The evaluation of leukocytes in response to the in vitro testing of ventricular assist devices. Artif Organs. 2013;37:793-801 pubmed publisher
	Abraham M, Kori I, Vishwakarma U, Goel S. Comprehensive assessment of goat adipose tissue-derived mesenchymal stem cells cultured in different media. Sci Rep. 2024;14:8380 pubmed publisher
	Yen F, Glusac J, Levi S, Zernov A, Baruch L, Davidovich Pinhas M, et al. Cultured meat platform developed through the structuring of edible microcarrier-derived microtissues with oleogel-based fat substitute. Nat Commun. 2023;14:2942 pubmed publisher
	Michelotti T, Kisby B, Flores L, Tegeler A, Fokar M, Crasto C, et al. Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows. Front Cell Dev Biol. 2022;10:1025240 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45 Monoclonal Antibody (1.11.32), PE

Catalog # :

MA1-81458

Quantity :

100 Tests

Price :

US 718.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Goat, Ovine

Applications :

Flow Cytometry: Neat

Species :

Bovine, Goat, Ovine

Clone :

1.11.32

Isotype :

IgG1

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Immunogen :

Ovine efferent lymphatic duct lymphocytes.

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: Neat

Aliases :

B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220

more info or order :

Invitrogen product webpage