product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD40 Monoclonal Antibody (3/23)
catalog :
MA1-81395
quantity :
500 ug
price :
US 622.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
23-Mar
reactivity :
mouse, rat
application :
ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2b
Sulek J, Robinson S, Petrossian A, Zhou S, Goliadze E, Manjili M, et al. Role of Epigenetic Modification and Immunomodulation in a Murine Prostate Cancer Model. Prostate. 2017;77:361-373 pubmed publisher
  • flow cytometry; mouse; fig 3
Iwami D, Zhang Q, Aramaki O, Nonomura K, Shirasugi N, Niimi M. Purified eicosapentaenoic acid induces prolonged survival of cardiac allografts and generates regulatory T cells. Am J Transplant. 2009;9:1294-307 pubmed publisher
  • immunocytochemistry; rat
Chen D, Carpenter A, Abrahams J, Chambers R, Lechler R, McVey J, et al. Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo. J Exp Med. 2008;205:1739-46 pubmed publisher
  • flow cytometry; mouse; fig 2
Zhang J, Raper A, Sugita N, Hingorani R, Salio M, Palmowski M, et al. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood. 2006;107:3600-8 pubmed
  • flow cytometry; rat
Savithri B, Khar A. A transmembrane-anchored rat RAE-1-like transcript as a ligand for NKR-P2, the rat ortholog of human and mouse NKG2D. Eur J Immunol. 2006;36:107-17 pubmed
  • flow cytometry; mouse; 1:50; fig 1
Freyschmidt E, Alonso A, Hartmann G, Gissmann L. Activation of dendritic cells and induction of T cell responses by HPV 16 L1/E7 chimeric virus-like particles are enhanced by CpG ODN or sorbitol. Antivir Ther. 2004;9:479-89 pubmed
  • flow cytometry; mouse
Morin J, Faideau B, Gagnerault M, Lepault F, Boitard C, Boudaly S. Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice. Clin Exp Immunol. 2003;134:388-95 pubmed
  • flow cytometry; mouse
Telega G, Baumgart D, Carding S. Uptake and presentation of antigen to T cells by primary colonic epithelial cells in normal and diseased states. Gastroenterology. 2000;119:1548-59 pubmed
  • flow cytometry; mouse; tbl 1
Bauman S, Nichols K, Murphy J. Dendritic cells in the induction of protective and nonprotective anticryptococcal cell-mediated immune responses. J Immunol. 2000;165:158-67 pubmed
Das S, Khar A. Regulation of NK cell function in vivo by the dose of tumour transplanted in the peritoneum. Immunol Lett. 2002;83:133-42 pubmed
Das S, Varalakshmi C, Kumari A, Patel M, Khar A. Target cell induced activation of NK cells in vitro: cytokine production and enhancement of cytotoxic function. Cancer Immunol Immunother. 2001;50:428-36 pubmed
Nagy H, Panis Y, Fabre M, Engelmann C, Soubrane O, Houssin D, et al. Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells. Biomed Pharmacother. 2000;54:479-86 pubmed
Jyothi M, Khar A. Interleukin-2-induced nitric oxide synthase and nuclear factor-kappaB activity in activated natural killer cells and the production of interferon-gamma. Scand J Immunol. 2000;52:148-55 pubmed
Das S, Varalakshmi C, Khar A. Target-cell-induced anergy in natural killer cells: suppression of cytotoxic function. Cancer Immunol Immunother. 2000;49:109-15 pubmed
Benedetti S, Bruzzone M, Pollo B, DiMeco F, Magrassi L, Pirola B, et al. Eradication of rat malignant gliomas by retroviral-mediated, in vivo delivery of the interleukin 4 gene. Cancer Res. 1999;59:645-52 pubmed
Rao K, Varalakshmi C, Ali A, Khar A. Administration of anti-IL-12 antibody in vivo inhibits rejection of a rat histiocytoma and suppresses cytokine response in a tumour-bearing host. Immunology. 1997;92:381-7 pubmed
Grazia Cifone M, Roncaioli P, Cironi L, Festuccia C, Meccia A, D Alò S, et al. NKR-P1A stimulation of arachidonate-generating enzymes in rat NK cells is associated with granule release and cytotoxic activity. J Immunol. 1997;159:309-17 pubmed
Goddard D, Bomalaski J, Lipper S, Shorr R, Clark M. Phospholipase A2-mediated inflammation induces regression of malignant gliomas. Cancer Lett. 1996;102:1-6 pubmed
Bright J, Kausalya S, Khar A. Natural killer cell activation-associated induction of target cell DNA fragmentation in a spontaneously regressing rat histiocytoma. Immunology. 1995;85:638-44 pubmed
Vukanovic J, Isaacs J. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers. Cancer Res. 1995;55:1499-504 pubmed
Chambers W, Vujanovic N, DeLeo A, Olszowy M, Herberman R, Hiserodt J. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells. J Exp Med. 1989;169:1373-89 pubmed
product information
Product Type :
Antibody
Product Name :
CD40 Monoclonal Antibody (3/23)
Catalog # :
MA1-81395
Quantity :
500 ug
Price :
US 622.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Flow Cytometry: 1:50, Functional Assay: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent
Species :
Mouse
Clone :
23-Mar
Isotype :
IgG2a
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Immunogen :
Extracellular domain of Murine CD40 and the Fc portion of Human IgG1.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Flow Cytometry: 1:50, Functional Assay: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent
Aliases :
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA