Estrogen Receptor beta Monoclonal Antibody (PPG5/10) | Invitrogen MA1-81281 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Estrogen Receptor beta Monoclonal Antibody (PPG5/10)

catalog :

MA1-81281

quantity :

100µL

price :

US 199.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PPG5/10

reactivity :

human, rat, pig, sheep

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 9

Published Application/Species/Dilution	Reference
western blot; human; 1:100; fig 1c	Nelson A, Groen A, Miller J, Warren A, Holmes K, Tarulli G, et al. Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity. Mol Cell Endocrinol. 2017;440:138-150 pubmed publisher
immunohistochemistry - paraffin section; human	Welsh A, Harigopal M, Wimberly H, Prasad M, Rimm D. Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5. Appl Immunohistochem Mol Morphol. 2013;21:139-47 pubmed publisher
	Sathish V, Freeman M, Long E, Thompson M, Pabelick C, Prakash Y. Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle. Cell Physiol Biochem. 2015;36:1101-15 pubmed publisher
	Hieken T, Carter J, Hawse J, Hoskin T, Bois M, Frost M, et al. ERβ expression and breast cancer risk prediction for women with atypias. Cancer Prev Res (Phila). 2015;8:1084-92 pubmed publisher
	Tan W, Boorjian S, Advani P, Farmer S, Lohse C, Cheville J, et al. The Estrogen Pathway: Estrogen Receptor-α, Progesterone Receptor, and Estrogen Receptor-β Expression in Radical Cystectomy Urothelial Cell Carcinoma Specimens. Clin Genitourin Cancer. 2015;13:476-84 pubmed publisher
	Beck A, Brooks A, Zeiss C. Invasive ductular carcinoma in 2 rhesus macaques (Macaca mulatta). Comp Med. 2014;64:314-22 pubmed
	Reese J, Suman V, Subramaniam M, Wu X, Negron V, Gingery A, et al. ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer. BMC Cancer. 2014;14:749 pubmed publisher
	Wu X, Subramaniam M, Negron V, Cicek M, Reynolds C, Lingle W, et al. Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody. J Cell Biochem. 2012;113:711-23 pubmed publisher
	Hanna J, Wimberly H, Kumar S, Slack F, Agarwal S, Rimm D. Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization. Biotechniques. 2012;52:235-45 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Estrogen Receptor beta Monoclonal Antibody (PPG5/10)

Catalog # :

MA1-81281

Quantity :

100µL

Price :

US 199.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Camelid, Human, Non-human primate, Ovine, Porcine, Rat, Reptile

Applications :

Immunofluorescence: Assay dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): 1/5-1/50

Species :

Camelid, Human, Non-human primate, Ovine, Porcine, Rat, Reptile

Clone :

PPG5/10

Isotype :

IgG2a

Storage :

4°C or -20°C if preferred

Description :

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).

Immunogen :

Synthetic peptide derived from the C terminus of the human estrogen receptor beta 1 isoform, CEDSKSKEGSQNPQSQ.

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: Assay dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): 1/5-1/50

Aliases :

PMPMEase

PubMed References :

22095450, 22482439, 25288324, 25296018, 25981333, 26113109, 26276747