CD204 Monoclonal Antibody (2F8), FITC | Invitrogen MA1-81060 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD204 Monoclonal Antibody (2F8), FITC

catalog :

MA1-81060

quantity :

100 ug

price :

US 438.00

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

2F8

reactivity :

mouse, pigs

application :

western blot, flow cytometry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500	Choi C, Hao L, Narayan S, Auyeung E, Mirkin C. Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proc Natl Acad Sci U S A. 2013;110:7625-30 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD204 Monoclonal Antibody (2F8), FITC

Catalog # :

MA1-81060

Quantity :

100 ug

Price :

US 438.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Fish, Mouse, Porcine

Applications :

Flow Cytometry: Neat

Species :

Fish, Mouse, Porcine

Clone :

2F8

Isotype :

IgG2b

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles. Store in the dark.

Description :

CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.

Immunogen :

RAW264 cell line.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Neat

Aliases :

bovine scavenger receptor type II; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; macrophage scavenger receptor types I and II; MRS-A; MSR; Msr1; MSR-A; phSR1; phSR2; RGD1564316; SCARA1; Scavenger receptor class A member 1; scavenger receptor class A, member 1; scavenger receptor type A; scavenger receptor type I; Scvr; SRA; SR-A; SR-AI; SR-AI/II; SR-AII

more info or order :

Invitrogen product webpage