CD44 Monoclonal Antibody (MAC329) | Invitrogen MA1-80974 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD44 Monoclonal Antibody (MAC329)

catalog :

MA1-80974

quantity :

2 mL

price :

US 399.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MAC329

reactivity :

goat, dog, cow, pig, sheep, equine

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

CD44 Monoclonal Antibody (MAC329)

Catalog # :

MA1-80974

Quantity :

2 mL

Price :

US 399.00

Clonality :

Monoclonal

Host :

Rat

Reactivity :

Bovine, Canine, Equine, Goat, Ovine, Porcine

Applications :

Flow Cytometry: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Immunoprecipitation: Assay Dependent

Species :

Bovine, Canine, Equine, Goat, Ovine, Porcine

Clone :

MAC329

Isotype :

IgG1

Storage :

4°C or -20°C if preferred

Description :

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

Immunogen :

Purified porcine wCD44.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Immunoprecipitation: Assay Dependent

Aliases :

CD44 antigen, Cell surface glycoprotein CD44, hyaluronate binding protein, ECMR-III, GP90 lymphocyte homing adhesion receptor, HUTCH-I, PGP-1, extracellular matrix receptor III, hermes antigen, hyaluronate receptor, phagocytic glycoprotein 1, phagocytic glycoprotein I