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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
alpha Tubulin Monoclonal Antibody (YOL1/34)
catalog :
MA1-80189
quantity :
500 ug
price :
US 520.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
YOL1/34
reactivity :
Candida albicans, Saccharomyces cerevisiae S288C, human, mouse, fruit fly
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot; fruit fly ; loading ...; fig 1f
Nil Z, Herv s R, Gerbich T, Leal P, Yu Z, Saraf A, et al. Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo. Cell. 2019;178:1403-1420.e21 pubmed publisher
  • immunocytochemistry; Candida albicans; 1:100
Thakur J, Sanyal K. A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. PLoS Genet. 2012;8:e1002661 pubmed publisher
Simpson L, Fulcher L, Sathe G, Brewer A, Zhao J, Squair D, et al. An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation. Cell Chem Biol. 2023;30:188-202.e6 pubmed publisher
Leong E, Khaing N, Cadot B, Hong W, Kozlov S, Werner H, et al. Nesprin-1 LINC complexes recruit microtubule cytoskeleton proteins and drive pathology in Lmna-mutant striated muscle. Hum Mol Genet. 2023;32:177-191 pubmed publisher
Simpson L, Glennie L, Brewer A, Zhao J, Crooks J, Shpiro N, et al. Target protein localization and its impact on PROTAC-mediated degradation. Cell Chem Biol. 2022;29:1482-1504.e7 pubmed publisher
Guo A, Huang H, Zhu Z, Chen M, Shi H, Yuan S, et al. cBAF complex components and MYC cooperate early in CD8+ T cell fate. Nature. 2022;607:135-141 pubmed publisher
Liedmann S, Liu X, Guy C, Crawford J, Rodriguez D, Kuzuoğlu Öztürk D, et al. Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. Mol Cell. 2022;82:2401-2414.e9 pubmed publisher
Hibshman J, Goldstein B. LEA motifs promote desiccation tolerance in vivo. BMC Biol. 2021;19:263 pubmed publisher
Nsamba E, Bera A, Costanzo M, Boone C, Gupta M. Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis. J Cell Biol. 2021;220: pubmed publisher
Dunbar K, MacArtney T, Sapkota G. IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling. Life Sci Alliance. 2021;4: pubmed publisher
Dunbar K, Jones R, Dingwell K, MacArtney T, Smith J, Sapkota G. FAM83F regulates canonical Wnt signalling through an interaction with CK1α. Life Sci Alliance. 2021;4: pubmed publisher
Shor E, Garcia Rubio R, DeGregorio L, Perlin D. A Noncanonical DNA Damage Checkpoint Response in a Major Fungal Pathogen. MBio. 2020;11: pubmed publisher
Simpson L, MacArtney T, Nardin A, Fulcher L, R th S, Testa A, et al. Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System. Cell Chem Biol. 2020;27:1164-1180.e5 pubmed publisher
R th S, MacArtney T, Konopacka A, Chan K, Zhou H, Queisser M, et al. Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System. Cell Chem Biol. 2020;27:1151-1163.e6 pubmed publisher
Kaczmarek Michaels K, Mohd Mostafa S, Ruiz Capella J, Moore C. Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases. Nucleic Acids Res. 2020;48:5407-5425 pubmed publisher
McElmurry K, Stone J, Ma D, Lamoureux P, Zhang Y, Steidemann M, et al. Dynein-mediated microtubule translocation powering neurite outgrowth in chick and Aplysia neurons requires microtubule assembly. J Cell Sci. 2020;133: pubmed publisher
Tachie Menson T, Gázquez Gutiérrez A, Fulcher L, MacArtney T, Wood N, Varghese J, et al. Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H. Cell Signal. 2020;72:109632 pubmed publisher
Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed publisher
Manak M, Varsanik J, Hogan B, Whitfield M, Su W, Joshi N, et al. Live-cell phenotypic-biomarker microfluidic assay for the risk stratification of cancer patients via machine learning. Nat Biomed Eng. 2018;2:761-772 pubmed publisher
Bozatzi P, Dingwell K, Wu K, Cooper F, Cummins T, Hutchinson L, et al. PAWS1 controls Wnt signalling through association with casein kinase 1α. EMBO Rep. 2018;19: pubmed publisher
Li F, Sawada J, Komatsu M. R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature. Nat Commun. 2017;8:1720 pubmed publisher
Kesavardhana S, Kuriakose T, Guy C, Samir P, Malireddi R, Mishra A, et al. ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. J Exp Med. 2017;214:2217-2229 pubmed publisher
Li X, Rayman J, Kandel E, Derkatch I. Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton. Mol Cell. 2014;55:305-18 pubmed publisher
product information
Product Type :
Antibody
Product Name :
alpha Tubulin Monoclonal Antibody (YOL1/34)
Catalog # :
MA1-80189
Quantity :
500 ug
Price :
US 520.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Human, Mouse, Yeast
Applications :
ELISA: 10 ug/mL as detecting antibody, Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Radioimmune assays: Assay-dependent, Western Blot: 2 ug/mL
Species :
Human, Mouse, Yeast
Clone :
YOL1/34
Isotype :
IgG2a
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Alpha Tubulin is a part of a heterodimer consisting of alpha and beta tubulin subunits. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha-beta tubulin heterodimer is the basic building block of microtubules, and this intracellular cylindrical filamentous structure is present in almost eukaryotic cells. Microtubules serve as structural supports and lines of transport within the cell, as well as serving a key role in mitosis. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. The gene that encodes alpha tubulin is highly similar to the mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells.
Immunogen :
Yeast tubulin.
Format :
Liquid
Applications w/Dilutions :
ELISA: 10 ug/mL as detecting antibody, Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Radioimmune assays: Assay-dependent, Western Blot: 2 ug/mL
Aliases :
&agr-tubulin 84B; 1t; a1t; ALPHA 84C; alpha tubulin; alpha tubulin 84B; alpha[[1]] tubulin; alpha[[1]]-tubulin; alpha1; alpha1 tubulin; alpha1t; alpha1tub; alpha1tub84B; alpha1-tubulin; alpha84B; alphaT; alphat-1; alphatub; alpha-tub; alphaTub1; alphatub84; alphaTUB84B; alpha-tub84B; alphaTub84B-PA; alphatubulin; alpha-tubulin; Alpha-tubulin 1; Alpha-tubulin 2; Alpha-tubulin 3; Alpha-tubulin 3C; alpha-tubulin 3C/D; Alpha-tubulin 3D; Alpha-tubulin 3E; alpha-tubulin 4; Alpha-tubulin 6; alphaTubulin 84B; alpha-Tubulin 84B; alpha-Tubulin at 84B; alpha-tubulin I; Alpha-tubulin II; alpha-tubulin III; Alpha-tubulin isotype M-alpha-1; alpha-tubulin isotype M-alpha-2; Alpha-tubulin isotype M-alpha-4; alpha-tubulin isotype M-alpha-6; alpha-tubulin TUB1; alpha-tubulin ubiquitous; alphaTubulin84B; Alpha-Tubulin84B; ALS22; anon-EST:Liang-1.59; anon-EST:Liang-2.30; AT25469p; aTub84B; a-tub84B; bA408E5.3; B-ALPHA-1; bcm948; BEST:LD32507; cb944; CG1913; CG1913-PA; chr3R:2914276. 2914416; clone 1.59; clone 2.30; Detyrosinated tubulin alpha-1A chain; Detyrosinated tubulin alpha-1B chain; Detyrosinated tubulin alpha-1C chain; Detyrosinated tubulin alpha-3 chain; Detyrosinated tubulin alpha-3C chain; Detyrosinated tubulin alpha-3D chain; Detyrosinated tubulin alpha-3E chain; DM1alpha; Dmel CG1913; Dmel_CG1913; DTA1; fb22g06; FLJ30169; H2 ALPHA; H2-ALPHA; hum-a-tub1; hum-a-tub2; I79_019110; K-ALPHA-1; l(3)84Bd; l(3)g3; lis3; LOC100726777; LOC100731885; LOC100857858; LOC101118307; LOC106557476; M[a]4; M[a]6; ms(3)nc33; nc33; RGD1565476; similar to alpha-tubulin isoform 1; similar to tubulin alpha 1; T; Talpha1; Talpha1 alpha-tubulin; TBA1_DROME; Testis-specific alpha-tubulin; Tub; Tub 84B; TUB1; Tub1C; Tub84B; TUBA1; Tuba-1; tuba1 protein; TUBA1/3/4; Tuba1a; tuba1a.L; tuba1a-a; tuba1a-b; TUBA1B; TUBA1C; tuba1l; tuba1l2; TUBA2; TUBA3; TUBA3C; TUBA3D; TUBA3E; Tuba4; Tuba4a; TUBA5; Tuba6; tuba8.S; tubA84B; tubal2; Tubalpha1; tubulin; tubulin 1 alpha-chain; tubulin 1alpha; tubulin alpha; tubulin alpha 1a; tubulin alpha 1a L homeolog; tubulin alpha 1b; tubulin alpha 1c; tubulin alpha 3; tubulin alpha 3c; tubulin alpha 3e; tubulin alpha 4a; tubulin alpha 6; tubulin alpha 8 S homeolog; tubulin alpha1; tubulin alpha-1 chain; tubulin alpha1 promoter; Tubulin alpha-1A chain; tubulin alpha-1B chain; Tubulin alpha-1C chain; tubulin alpha-1C chain-like; tubulin alpha-2 chain; Tubulin alpha-3 chain; Tubulin alpha-3C chain; tubulin alpha-3C/D chain; Tubulin alpha-3D chain; Tubulin alpha-3E chain; tubulin alpha-4 chain; Tubulin alpha-4A chain; Tubulin alpha-5 chain; tubulin alpha-5 chain-like; tubulin alpha-6 chain; tubulin alpha-8 chain; tubulin alpha-ubiquitous chain; tubulin B-alpha-1; Tubulin H2-alpha; tubulin K-alpha-1; tubulin(alpha1); tubulin, alpha 1; tubulin, alpha 1 (testis specific); tubulin, alpha 1, like; tubulin, alpha 1, like 2; tubulin, alpha 1a; tubulin, alpha 1b; tubulin, alpha 1c; tubulin, alpha 2; tubulin, alpha 3c; tubulin, alpha 3e; tubulin, alpha 4; tubulin, alpha 4a; tubulin, alpha 5; tubulin, alpha 6; tubulin, alpha, brain-specific; tubulin, alpha, ubiquitous; tubulin1alpha; tubulin84B; Tubulin-alpha1; Unknown (protein for MGC:133894); unnamed protein product; wu:fb22g06; wu:fb37a10; XELAEV_18019849mg; XELAEV_18020901mg; YML085C
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA