CD68 Monoclonal Antibody (514H12) | Invitrogen MA1-80133 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD68 Monoclonal Antibody (514H12)

catalog :

MA1-80133

quantity :

100 uL

price :

US 252.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

514H12

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 1f	Wang Y, Chaffee T, LaRue R, Huggins D, Witschen P, Ibrahim A, et al. Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice. elife. 2020;9: pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 8	Izumi K, Fang L, Mizokami A, Namiki M, Li L, Lin W, et al. Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation. EMBO Mol Med. 2013;5:1383-401 pubmed publisher
	Poels K, Schnitzler J, Waissi F, Levels J, Stroes E, Daemen M, et al. Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability. Front Cell Dev Biol. 2020;8:581641 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD68 Monoclonal Antibody (514H12)

Catalog # :

MA1-80133

Quantity :

100 uL

Price :

US 252.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:40-1:80

Species :

Human

Clone :

514H12

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.

Immunogen :

Fusion protein of external domain of human CD68.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:40-1:80

Aliases :

CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen

more info or order :

Invitrogen product webpage