MMP2 Monoclonal Antibody (F14 P4 D3) | Invitrogen MA1-772 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MMP2 Monoclonal Antibody (F14 P4 D3)

catalog :

MA1-772

quantity :

100 µg

price :

US 430.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

F14 P4 D3

reactivity :

human, rat, bovine

application :

western blot, ELISA

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; fig 3a	Shi D, Shi G, Xie J, Du X, Yang H. MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis. Mol Cells. 2016;39:611-8 pubmed publisher
western blot; bovine	Kono M, Crouch R. In vitro assays of rod and cone opsin activity: retinoid analogs as agonists and inverse agonists. Methods Mol Biol. 2010;652:85-94 pubmed publisher
	Calle A, Toribio V, Y xe1 xf1 ez M xf3 M, Ram xed rez M. Embryonic Trophectoderm Secretomics Reveals Chemotactic Migration and Intercellular Communication of Endometrial and Circulating MSCs in Embryonic Implantation. Int J Mol Sci. 2021;22: pubmed publisher
	Fan Y, Wang K. miR‑205 suppresses cell migration, invasion and EMT of colon cancer by targeting mouse double minute 4. Mol Med Rep. 2020;22:633-642 pubmed publisher
	Zhu W, Li W, Geng Q, Wang X, Sun W, Jiang H, et al. Silence of Stomatin-Like Protein 2 Represses Migration and Invasion Ability of Human Liver Cancer Cells via Inhibiting the Nuclear Factor Kappa B (NF-κB) Pathway. Med Sci Monit. 2018;24:7625-7632 pubmed publisher
	Zhang Y, Zhang Y. Forkhead box C2 promotes the invasion ability of human trophoblast cells through Hedgehog (Hh) signaling pathway. Cell Biol Int. 2018;42:859-866 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MMP2 Monoclonal Antibody (F14 P4 D3)

Catalog # :

MA1-772

Quantity :

100 µg

Price :

US 430.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Rat

Applications :

ELISA: 1-2 µg, Western Blot: 1:200-1:500

Species :

Human, Rat

Clone :

F14 P4 D3

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.

Immunogen :

Synthetic peptide corresponding to residues T(557) S L G L P P D V Q R V D(569) of human MMP-2.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-2 µg, Western Blot: 1:200-1:500

Aliases :

72 kDa gelatinase; 72 kDa type IV collagenase; 72 kDa type IV collagenase isoform a preproprotein; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; endopeptidase; GelA; gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP2; MMP-2; MMP-2 protein; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; prepro-72kDa matrix metalloproteinase; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01

more info or order :

Invitrogen product webpage