CD20 Monoclonal Antibody (B9E9) | Invitrogen MA1-7634 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD20 Monoclonal Antibody (B9E9)

catalog :

MA1-7634

quantity :

100 ug

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

B9E9

reactivity :

human, mouse, rat, rhesus macaque

application :

ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rat; 1:100	Rönkkö S, Kaarniranta K, Kalesnykas G, Uusitalo H. Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats. Ophthalmic Res. 2011;46:55-65 pubmed publisher
immunocytochemistry; rhesus macaque immunohistochemistry; rhesus macaque	Estes J, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C, et al. Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection. J Infect Dis. 2007;195:551-61 pubmed
	Joo H, Lee Y, Kim J, Yoo J, Yoo S, Kim S, et al. Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures. Sci Adv. 2021;7: pubmed publisher
	Colinot D, Garbuz T, Bosland M, Wang L, Rice S, Sullivan W, et al. The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model. Prostate. 2017;77:1066-1075 pubmed publisher
	Manshouri T, Do K, Wang X, Giles F, O Brien S, Saffer H, et al. Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance. Blood. 2003;101:2507-13 pubmed

product information

Product Type :

Antibody

Product Name :

CD20 Monoclonal Antibody (B9E9)

Catalog # :

MA1-7634

Quantity :

100 ug

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: 1:500, Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:50, Immunoprecipitation: 1:50

Species :

Human, Mouse

Clone :

B9E9

Isotype :

IgG2a

Storage :

4 C short term, -80 C long term

Description :

CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.

Immunogen :

CD20, Human white blood cell fraction

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:500, Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:50, Immunoprecipitation: 1:50

Aliases :

AA960661; APY; ATOPY; B1; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; Cd20; CD20 antigen; CD20 cell surface protein; CD20 receptor; CVID5; EGK_06167; Fc epsilon receptor I beta chain; Fc Fragment of IgE high affinity I receptor for beta polypeptide; FCER1B; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; IGEL; IGER; IGHER; LEU16; LEU-16; Leukocyte surface antigen Leu-16; Ly44; Ly-44; Lymphocyte antigen 44; membrane spanning 4-domains A1; membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; MGC3969; MS4A1; MS4A2; S7

more info or order :

Invitrogen product webpage