PSEN2 Monoclonal Antibody (APS 21) | Invitrogen MA1-753 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSEN2 Monoclonal Antibody (APS 21)

catalog :

MA1-753

quantity :

200 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

APS 21

The same clone is also sold as:

Novus Biologicals: NB100-74512

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Diehlmann A, Ida N, Weggen S, Grunberg J, Haass C, Masters C, et al. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. J Neurosci Res. 1999;56:405-19 pubmed

product information

Product Type :

Antibody

Product Name :

PSEN2 Monoclonal Antibody (APS 21)

Catalog # :

MA1-753

Quantity :

200 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

ELISA: 4.5 ug/mL, Immunocytochemistry: 0.75 ug/mL, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:100-1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

APS 21

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Immunogen :

Synthetic peptide corresponding to residues C(31) Q E G R Q G P E D G E N T A(45) of human PS2.

Format :

Liquid

Applications w/Dilutions :

ELISA: 4.5 ug/mL, Immunocytochemistry: 0.75 ug/mL, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:100-1:1,000

Aliases :

AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; PSEN2; Psnl2; STM2; STM-2