Presenilin 1 Monoclonal Antibody (APS 18) | Invitrogen MA1-752 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Presenilin 1 Monoclonal Antibody (APS 18)

catalog :

MA1-752

quantity :

200 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

APS 18

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:250; tbl 1 western blot; mouse; 1:250; tbl 1	Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. Î²-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
western blot; mouse	Shimada I, LeComte M, Granger J, Quinlan N, Spees J. Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci. 2012;32:7926-40 pubmed publisher
	Ulku I, Liebsch F, Akerman S, Schulz J, Kulic L, Hock C, et al. Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis. Sci Rep. 2023;13:2216 pubmed publisher
	Diehlmann A, Ida N, Weggen S, Grunberg J, Haass C, Masters C, et al. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. J Neurosci Res. 1999;56:405-19 pubmed
	Stahl B, Diehlmann A, Sudhof T. Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J Biol Chem. 1999;274:9141-8 pubmed
	Tesco G, Kim T, Diehlmann A, Beyreuther K, Tanzi R. Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem. 1998;273:33909-14 pubmed

product information

Product Type :

Antibody

Product Name :

Presenilin 1 Monoclonal Antibody (APS 18)

Catalog # :

MA1-752

Quantity :

200 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

ELISA: 1:1,000, Immunocytochemistry: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:20 - 1:200, Western Blot: 1:50-1:500

Species :

Human, Mouse, Non-human primate, Rat

Clone :

APS 18

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

Immunogen :

Synthetic peptide corresponding to residues C S(313) K Y N A E S T E R E S Q D T V A E N D D G(334) of humen PS1.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:1,000, Immunocytochemistry: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:20 - 1:200, Western Blot: 1:50-1:500

Aliases :

AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1

more info or order :

Invitrogen product webpage