PrP Monoclonal Antibody (F89/160.1.5) | Invitrogen MA1-750 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PrP Monoclonal Antibody (F89/160.1.5)

catalog :

MA1-750

quantity :

200 µg

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

F89/160.1.5

reactivity :

hamsters, human, mouse, bovine, domestic sheep

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
ELISA; hamsters; 5 ug/ml	An S, Lim K, Oh H, Lee B, Zukic E, Ju Y, et al. Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System. Biochem Biophys Res Commun. 2010;392:505-9 pubmed publisher
	O Rourke K, Baszler T, Besser T, Miller J, Cutlip R, Wells G, et al. Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue. J Clin Microbiol. 2000;38:3254-9 pubmed
	Pammer J, Cross H, Frobert Y, Tschachler E, Oberhuber G. The pattern of prion-related protein expression in the gastrointestinal tract. Virchows Arch. 2000;436:466-72 pubmed
	O Rourke K, Baszler T, Miller J, Spraker T, Sadler Riggleman I, Knowles D. Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein. J Clin Microbiol. 1998;36:1750-5 pubmed
	O Rourke K, Baszler T, Parish S, Knowles D. Preclinical detection of PrPSc in nictitating membrane lymphoid tissue of sheep. Vet Rec. 1998;142:489-91 pubmed

product information

Product Type :

Antibody

Product Name :

PrP Monoclonal Antibody (F89/160.1.5)

Catalog # :

MA1-750

Quantity :

200 µg

Price :

US 471.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Cervidae, Human, Mouse, Ovine

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 3-5 µg/mL, Western Blot: 3-5 µg/mL

Species :

Bovine, Cervidae, Human, Mouse, Ovine

Clone :

F89/160.1.5

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.

Immunogen :

Synthetic peptide corresponding to residues S(146) R P L I H F G S D Y E D R(159) of bovine PrP.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 3-5 µg/mL, Western Blot: 3-5 µg/mL

Aliases :

AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP ; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE

more info or order :

Invitrogen product webpage