Ricin beta Monoclonal Antibody (RB999) | Invitrogen MA1-74237 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ricin beta Monoclonal Antibody (RB999)

catalog :

MA1-74237

quantity :

200 µg

price :

US 405.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RB999

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

Ricin beta Monoclonal Antibody (RB999)

Catalog # :

MA1-74237

Quantity :

200 µg

Price :

US 405.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Plant

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Plant

Clone :

RB999

Isotype :

IgG1

Storage :

4°C or -20°C if preferred

Description :

Ricin toxin is a 60 kDa glycoprotein that consists of two chains, A and B, covalently linked by a disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essential for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from the castor bean (Ricinus communis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, although a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for biological warfare although it is less stable than other agents, such as anthrax.

Immunogen :

Proprietary sequence

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent