HIV1 Tat Monoclonal Antibody (7) | Invitrogen MA1-71509 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HIV1 Tat Monoclonal Antibody (7)

catalog :

MA1-71509

quantity :

100 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, Human immunodeficiency virus 1

application :

western blot, ELISA, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; loading ...; fig 6c	Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019;129:3361-3373 pubmed publisher
	Li X, Guo Y, Li H, Huang X, Pei Z, Wang X, et al. Infection by Diverse HIV-1 Subtypes Leads to Different Elevations in HERV-K Transcriptional Levels in Human T Cell Lines. Front Microbiol. 2021;12:662573 pubmed publisher
	Alamer E, Zhong C, Liu Z, Niu Q, Long F, Guo L, et al. Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580. J Virol. 2020;94: pubmed publisher

product information

Product Type :

Antibody

Product Name :

HIV1 Tat Monoclonal Antibody (7)

Catalog # :

MA1-71509

Quantity :

100 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Virus

Applications :

ChIP Assay: 1-3 uL, ELISA: 0.2-1 ug/mL, Western Blot: 1-2 ug/mL

Species :

Virus

Clone :

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

HIV-1 Tat ('Trans-Activator of Transcription') consists of 86 to 101 amino acids depending on the subtype. Tat is critical to HIV reproduction by way of compensating for a defect in its genome: the HIV RNA initially has a hairpin-structured portion which prevents full transcription from occurring. However, a small number of RNA transcripts will be made, which allow the Tat protein to be produced. Tat then binds to and phosphorylates cellular factors, eliminating the effect of the hairpin RNA structure and allowing transcription of the HIV RNA. This increases the rate of transcription, providing a positive feedback cycle. The protein is released by infected cells in culture, and is found in the blood of HIV-1 infected patients.

Immunogen :

Recombinant Tat protein of HIV-1 BH10 purified from E. coli

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1-3 uL, ELISA: 0.2-1 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

HIV-1 Tat

more info or order :

Invitrogen product webpage