HIV1 nef Monoclonal Antibody (2H12) | Invitrogen MA1-71505 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HIV1 nef Monoclonal Antibody (2H12)

catalog :

MA1-71505

quantity :

100 ug

price :

US 464.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H12

reactivity :

Human immunodeficiency virus 1

application :

western blot, ELISA, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; Human immunodeficiency virus 1; loading ...; fig s5a western blot; Human immunodeficiency virus 1; 1:1000; loading ...; fig 1b, 1c, 1d, 2a, 5a	Castro Gonzalez S, Shi Y, Colomer Lluch M, Song Y, Mowery K, Almodovar S, et al. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy. 2020;:1-25 pubmed publisher
	Shi Y, Simpson S, Ahmed S, Chen Y, Tavakoli Tameh A, Janaka S, et al. The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA. Viruses. 2023;15: pubmed publisher
	Castro Gonzalez S, Chen Y, Benjamin J, Shi Y, Serra Moreno R. Residues T48 and A49 in HIV-1 NL4-3 Nef are responsible for the counteraction of autophagy initiation, which prevents the ubiquitin-dependent degradation of Gag through autophagosomes. Retrovirology. 2021;18:33 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HIV1 nef Monoclonal Antibody (2H12)

Catalog # :

MA1-71505

Quantity :

100 ug

Price :

US 464.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Virus

Applications :

ELISA: 0.02-0.06 ug/mL, Western Blot: 0.8 ug/mL

Species :

Virus

Clone :

2H12

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

HIV-1 Nef is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The name derives from its negative factor thought at the beginning but presently it is remarked as the protein which bears a most distinctive biological characteristic of AIDS virus. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of receptor protein of the cell surface such as CD 4 and MH4, important for AIDS virus infection.

Immunogen :

Recombinant Nef protein of HIV-1 BRU purified from E. coli

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.02-0.06 ug/mL, Western Blot: 0.8 ug/mL

Aliases :

HIV-1 Nef

more info or order :

Invitrogen product webpage