This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Diphtheria Toxin Monoclonal Antibody (E53J)
catalog :
MA1-7027
quantity :
1 mL
price :
US 395.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E53J
product information
Product Type :
Antibody
Product Name :
Diphtheria Toxin Monoclonal Antibody (E53J)
Catalog # :
MA1-7027
Quantity :
1 mL
Price :
US 395.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Bacteria
Applications :
ELISA: 1:20 - 1:200
Species :
Bacteria
Clone :
E53J
Isotype :
IgG1
Storage :
4° C
Description :
Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology. The TM- and receptor binding-domains together constitute fragment B.
Immunogen :
C. diphtheria lysate.
Format :
Liquid
Applications w/Dilutions :
ELISA: 1:20 - 1:200
Aliases :
DT
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA