HLA-DR Monoclonal Antibody (YE2/36 HLK) | Invitrogen MA1-70112 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HLA-DR Monoclonal Antibody (YE2/36 HLK)

catalog :

MA1-70112

quantity :

500µg

price :

US 345

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

YE2/36 HLK

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50; fig 4	Bergler T, Jung B, Bourier F, Kühne L, Banas M, Rümmele P, et al. Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation. PLoS ONE. 2016;11:e0156900 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HLA-DR Monoclonal Antibody (YE2/36 HLK)

Catalog # :

MA1-70112

Quantity :

500µg

Price :

US 345

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Human

Applications :

Flow Cytometry: 1.0 µg/10^6 cells, Immunofluorescence: Assay dependent, Immunohistochemistry (Paraffin): Assay dependent

Species :

Human

Clone :

YE2/36 HLK

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

Immunogen :

EHR-B Ramos cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1.0 µg/10^6 cells, Immunofluorescence: Assay dependent, Immunohistochemistry (Paraffin): Assay dependent

Aliases :

human leukocyte antigens