I-Ak Monoclonal Antibody (14V.18) | Invitrogen MA1-70068 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

I-Ak Monoclonal Antibody (14V.18)

catalog :

MA1-70068

quantity :

250 µg

price :

US 376

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14V.18

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 3	Iwami D, Zhang Q, Aramaki O, Nonomura K, Shirasugi N, Niimi M. Purified eicosapentaenoic acid induces prolonged survival of cardiac allografts and generates regulatory T cells. Am J Transplant. 2009;9:1294-307 pubmed publisher
flow cytometry; mouse; fig 5	Magner W, Kazim A, Stewart C, Romano M, Catalano G, Grande C, et al. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J Immunol. 2000;165:7017-24 pubmed
	Krishnan B, Massilamany C, Basavalingappa R, Gangaplara A, Rajasekaran R, Afzal M, et al. Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice. J Immunol. 2018;200:523-537 pubmed publisher

product information

Product Type :

Antibody

Product Name :

I-Ak Monoclonal Antibody (14V.18)

Catalog # :

MA1-70068

Quantity :

250 µg

Price :

US 376

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/1 million cells

Species :

Mouse

Clone :

14V.18

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

MHC Class II (I-Ak) serves as a critical component of the immune system, facilitating the recognition and response to extracellular pathogens and foreign substances. Its primary role is to present peptides derived from extracellular proteins to T cells for immune recognition. MHC Class II (I-Ak) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove. The location of MHC Class II (I-Ak) is restricted to antigen-presenting cells, such as dendritic cells, macrophages, and B cells. These cells are responsible for capturing and processing antigens from the extracellular environment. MHC Class II (I-Ak) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane. The cytoplasmic tail plays a role in intracellular signaling events. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Immunogen :

A.TL.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/1 million cells

Aliases :

A alpha; Aalpha; H-2 class II histocompatibility antigen, A-B alpha chain; H-2 class II histocompatibility antigen, A-F alpha chain; H-2 class II histocompatibility antigen, A-K alpha chain; H-2 class II histocompatibility antigen, A-Q alpha chain; H-2 class II histocompatibility antigen, A-R alpha chain; H-2 class II histocompatibility antigen, A-S alpha chain; H-2 class II histocompatibility antigen, A-U alpha chain; H2Aa; H-2Aa; H2-Aa; histocompatibility 2, class II antigen A, alpha; Ia1; Ia-1; IAalpha; I-Aalpha; major histocompatibility protein class II alpha chain; MHC class II antigen A alpha isoform-004; MHC-II I-A(d) alpha

more info or order :

Invitrogen product webpage